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In this study, 379 vitiligo patients were recruited and divided into SV (33.2%), mild\u2010to\u2010moderate NSV (M\u2010NSV, affected body affected area [BSA] \u226410%, 34.0%), and severe NSV (S\u2010NSV, affected BSA &gt;10%, 32.7%) groups. Demographics and clinical data were collected through in\u2010person interviews. The disease activity, progression, and prognosis were assessed through 6\u00a0months\u2019 follow\u2010up. Serum cytokines profile and tissue\u2010<jats:italic>infiltrating<\/jats:italic> immune cells were measured by ELISA assay and immunofluorescence, respectively. The SV exhibited lower rates of autoimmune comorbidities and recurrence than the S\u2010NSV, but performed similar to the M\u2010NSV. Moreover, the disease activity, progression, serum cytokines profile, and tissue\u2010<jats:italic>infiltrating<\/jats:italic>\u00a0Th\/c1 cells in the active SV and M\u2010NSV were comparable, but differed significantly from those of the active S\u2010NSV. The clinical and immunological similarities between SV and M\u2010NSV presented a deeper autoimmune understanding of SV. Additionally, a classification of active vitiligo according to disease extent may be more clinically meaningful than subtypes for guiding immunomodulatory treatment.<\/jats:p>","DOI":"10.1111\/pcmr.13022","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:37:09Z","timestamp":1636983429000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New insights into segmental vitiligo: A clinical and immunological comparison with nonsegmental vitiligo"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-0428","authenticated-orcid":false,"given":"Xinya","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of 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