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Whole\u2010genome\/exome data from 181\u00a0samples were identified. Targeted panel sequencing data from MSK\u2010IMPACT were included as a validation cohort (<jats:italic>n\u00a0<\/jats:italic>=\u00a092), and studies using targeted hot spot sequencing were also collated for <jats:italic>BRAF<\/jats:italic> (<jats:italic>n\u00a0<\/jats:italic>=\u00a026\u00a0studies), <jats:italic>NRAS<\/jats:italic> (<jats:italic>n\u00a0<\/jats:italic>=\u00a021), and <jats:italic>KIT<\/jats:italic> (<jats:italic>n\u00a0<\/jats:italic>=\u00a032). Statistical analysis indicated <jats:italic>BRAF<\/jats:italic>, <jats:italic>NRAS<\/jats:italic>, <jats:italic>PTEN<\/jats:italic>, <jats:italic>TYRP1<\/jats:italic>, and <jats:italic>KIT<\/jats:italic> as significantly mutated genes. Frequent copy\u2010number aberrations were also found for important cancer genes, such as <jats:italic>CDKN2A<\/jats:italic>, <jats:italic>KIT<\/jats:italic>, <jats:italic>MDM2<\/jats:italic>, <jats:italic>CCND1<\/jats:italic>, <jats:italic>CDK4<\/jats:italic>, and <jats:italic>PAK1<\/jats:italic>, among others. Mapping genomic alterations within the context of the hallmarks of cancer identified four components frequently altered, including (i) sustained proliferative signaling and (ii) evading growth suppression, (iii) genome instability and mutation, and (iv) enabling replicative immortality. This analysis provides the largest analysis of genomic aberrations in AM in the literature to date and highlights pathways that may be therapeutically targetable.<\/jats:p>","DOI":"10.1111\/pcmr.13034","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T05:08:27Z","timestamp":1646111307000},"page":"369-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Systematic review and meta\u2010analysis of genomic alterations in acral melanoma"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-5437","authenticated-orcid":false,"given":"Natasa","family":"Broit","sequence":"first","affiliation":[{"name":"Oncogenomics Group QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland 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