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It often develops following cutaneous inflammation and is triggered by various stimuli, from inflammatory and autoimmune conditions to iatrogenic causes and mechanical injuries. While it is well established that an increase in melanin production and distribution within the epidermis and dermis is a hallmark feature of this condition, the exact mechanisms underlying PIH are not completely understood. This article aims to review the current evidence on the pathophysiology of PIH as the cellular and molecular mechanism of PIH represents a promising avenue for the development of novel, targeted therapies.<\/jats:p>","DOI":"10.1111\/pcmr.13038","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T08:39:51Z","timestamp":1647765591000},"page":"320-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["A Focused review on the pathophysiology of post\u2010inflammatory hyperpigmentation"],"prefix":"10.1111","volume":"35","author":[{"given":"Jalal","family":"Maghfour","sequence":"first","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadesola","family":"Olayinka","sequence":"additional","affiliation":[{"name":"Medical School SUNY Downstate Health Sciences University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iltefat H.","family":"Hamzavi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasneem F.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001518"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2011.0326"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12874"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23929.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23929.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-12-0842"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08717.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.168"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.2.C271"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33376"},{"issue":"5","key":"e_1_2_6_12_1","first-page":"18","article-title":"Psychosocial impact of postinflammatory hyperpigmentation in patients with acne vulgaris","volume":"10","author":"Darji K.","year":"2017","journal-title":"The Journal of Clinical and Aesthetic Dermatology"},{"issue":"7","key":"e_1_2_6_13_1","first-page":"20","article-title":"Postinflammatory hyperpigmentation: A review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis E. 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