{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:33:51Z","timestamp":1784349231611,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Combination immunotherapy with nivolumab and ipilimumab is an effective therapy in the treatment of metastatic melanoma, however, its benefit in older patients is unclear. A multicentre retrospective study was performed to compare the efficacy and toxicity of combination immunotherapy in metastatic melanoma in patients \u226565\u2009years versus &lt;65\u2009years, and complications of steroids used to manage toxicity. One hundred and thirty\u2010nine patients were included with 52 patients \u226565\u2009years (median age: 70; range: 65\u201383) and 87 patients &lt;65\u2009years (median age: 52; range: 22\u201364). Median overall survival was similar in patients \u226565\u2009years versus &lt;65\u2009years (14.9 vs. 17.3\u00a0months <jats:italic>p<\/jats:italic>\u00a0=\u2009.58). Median progression\u2010free survival was also similar in both groups (7.1 vs. 6.9\u00a0months <jats:italic>p<\/jats:italic>\u00a0=\u2009.79), as was overall response rate (48.1% vs. 44.8% <jats:italic>p<\/jats:italic>\u00a0=\u2009.73). Age was not associated with a difference in overall survival on multivariate analysis. There was similar rates of Grade 3 or higher adverse events in patients \u226565\u2009years versus &lt;65\u2009years (50% vs. 49% <jats:italic>p<\/jats:italic>\u00a0=\u20091.0) and discontinuation rates secondary to toxicity (55.8% vs. 56% <jats:italic>p<\/jats:italic>\u00a0=\u20091.0). Median duration of steroids used to treat adverse events was similar (11 vs. 12\u2009weeks <jats:italic>p<\/jats:italic>\u00a0=\u2009.46). Complications of steroids requiring inpatient admission was numerically higher in the older patients (41.3% vs. 20.4% <jats:italic>p<\/jats:italic>\u00a0=\u2009.07). Patients \u226565\u2009years received similar benefit from combination immunotherapy in comparison to their younger counterparts with similar toxicity.<\/jats:p>","DOI":"10.1111\/pcmr.13063","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T06:35:12Z","timestamp":1662446112000},"page":"587-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toxicity and response to ipilimumab and nivolumab in older patients with metastatic melanoma: A multicentre retrospective analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-253X","authenticated-orcid":false,"given":"Shivanshan","family":"Pathmanathan","sequence":"first","affiliation":[{"name":"Medical Oncology Department Royal Brisbane and Women's Hospital  Herston Queensland Australia"},{"name":"Medical Oncology Department Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Medical Oncology Department Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Babu","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-3282","authenticated-orcid":false,"given":"Marcin","family":"Dzienis","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Gold Coast University Hospital  Southport Queensland Australia"},{"name":"Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Azer","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Sunshine Coast University Hospital  Sunshine Coast Queensland Australia"},{"name":"Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Eastgate","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Gold Coast University Hospital  Southport Queensland Australia"},{"name":"University of Queensland  St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0450"},{"key":"e_1_2_8_3_1","unstructured":"Cancer Australia [Internet]. 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