{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:53:21Z","timestamp":1791996801530,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T00:00:00Z","timestamp":1665273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Segmental vitiligo (SV) is a unilateral subtype of vitiligo which is clinically characterized by a cutaneous depigmentation and histologically by a melanocyte loss from the epidermis and hair follicle reservoirs. To date, its pathogenesis remains a mystery. In many cases, this skin depigmentation shares several clinical features and dysfunctions with herpes zoster (HZ). So, for the first time, we examined whether any nucleus and cell fusion associated with a positive immunolabelling of varicella\u2010zoster virus (VZV) and VZV mature virions could be found in SV skin samples as in herpes zoster (HZ). A total of 40 SV samples were used for histological and immunochemical studies. Control samples were obtained from three HZ, and 10 generalized vitiligo lesions. For ultrastructural study, three recent SV and one HZ as controls were recruited. Here, we report that nuclear fusion in epidermal cells were statistically associated with recent SV (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001), whereas syncytia formation was associated with long\u2010lasting SV (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.001). A positive detection of VZV antigen was statistically associated in the epidermis with recent SV and in the dermis with long\u2010lasting SV (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.001). Finally, the discovery of mature virions in 3\/3 recent SV samples provides additional arguments for our viral hypothesis.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.13064","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T10:34:29Z","timestamp":1663324469000},"page":"78-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Varicella\u2010zoster virus in actively spreading segmental vitiligo skin: Pathological, immunochemical, and ultrastructural findings (a first and preliminary study)"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-8094","authenticated-orcid":false,"given":"Yvon","family":"Gauthier","sequence":"first","affiliation":[{"name":"Vitiligo and Melasma Research Association (V.M.R.A.)  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Lepreux","sequence":"additional","affiliation":[{"name":"Pathology Department Hopital Robert Boulin, CHR  Libourne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-5684","authenticated-orcid":false,"given":"Muriel","family":"Cario\u2010Andre","sequence":"additional","affiliation":[{"name":"Bordeaux University, INSERM, BRIC, U1312  Bordeaux France"},{"name":"National Reference Center for Rare skin Diseases Bordeaux University Hospital  Bordeaux France"},{"name":"Aquiderm  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Rambert","sequence":"additional","affiliation":[{"name":"National Reference Center for Rare skin Diseases Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Dakdaki","sequence":"additional","affiliation":[{"name":"Tumor Bank and Tumor Biology Laboratory CHU Bordeaux  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Edith","family":"Lafon","sequence":"additional","affiliation":[{"name":"Department of Virology Bordeaux University Hospital Bordeaux University, CNRS, UMR5234  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redouane","family":"Abouqal","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics, Clinical Research and Epidemiology Mohammed V University in Rabat, Acute Medical Unit, Ibn Sina Teaching Hospital  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-6563","authenticated-orcid":false,"given":"Laila","family":"Benzekri","sequence":"additional","affiliation":[{"name":"Dermatology Department, Ibn Sina Teaching Hospital Mohammed V University in Rabat, Pigmentary Disorders Outpatient Clinic  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12870"},{"key":"e_1_2_9_3_1","first-page":"124","article-title":"Vitiligo avec troubles nerveux sympathiques: l\u2019 origine sympathique du vitiligo","volume":"12","author":"Arnozan X.","year":"1922","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Syphiligraphie"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.119949"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.181463"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00138.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.377"},{"issue":"8","key":"e_1_2_9_8_1","first-page":"000181","article-title":"Viral causes of vitiligo: A new perspective for vitiligo pathogenesis","volume":"2","author":"Dwiwedi M.","year":"2018","journal-title":"Virology & Immunology Journal"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10709.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.031"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j1755\u20101488.201200997x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7241\/ourd.20142.37"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69361-1_34"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy407"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000258"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2018.06.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16352"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90490-9"},{"key":"e_1_2_9_19_1","first-page":"100","article-title":"Herpes zoster cases following Blashko\u2010lines","volume":"2","author":"Gyula N.","year":"1982","journal-title":"Borgyogyaszati es Venerolog iai Szemle"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.8.4994-5010.1995"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2927"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130411.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.156448"},{"key":"e_1_2_9_24_1","first-page":"543","article-title":"A case of segmental vitiligo occuring where herpes zoster occured previously as an isomorphic response","volume":"56","author":"Kim J. 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