{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:39:26Z","timestamp":1789439966324,"version":"build-2803163510"},"reference-count":192,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001513","name":"Breast Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002224","name":"Melanoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017331","name":"Ministerium f\u00fcr Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metastatic melanoma is a complex and deadly disease. Due to its complexity, the development of novel therapeutic strategies to inhibit metastatic melanoma remains an outstanding challenge. Our ability to study metastasis is advanced with the development of in vitro and in vivo models that better mimic the different steps of the metastatic cascade beginning from primary tumor initiation to final metastatic seeding. In this review, we provide a comprehensive summary of in vitro models, in vivo models, and in silico platforms to study the individual steps of melanoma metastasis. Furthermore, we highlight the advantages and limitations of each model and discuss the challenges of how to improve current models to enhance translation for melanoma cancer patients and future therapies.<\/jats:p>","DOI":"10.1111\/pcmr.13078","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T17:28:19Z","timestamp":1670434099000},"page":"206-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Advancements in melanoma cancer metastasis models"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-5220","authenticated-orcid":false,"given":"Luiza Martins","family":"Nascentes\u00a0Melo","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Essen and German Cancer Consortium  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen and German Cancer Consortium  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Riess","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen and German Cancer Consortium  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystina J.","family":"Szylo","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Eisenburger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen and German Cancer Consortium  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen and German Cancer Consortium  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessalyn M.","family":"Ubellacker","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-852X","authenticated-orcid":false,"given":"Alpaslan","family":"Tasdogan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Essen and German Cancer Consortium  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6509"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06639"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.491"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010019\u20100154\u20104"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20102725"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2120617119"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5658"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0lc00988a"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13111"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3791\/53486"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095723"},{"issue":"3","key":"e_1_2_11_13_1","first-page":"231","article-title":"Antitumor action of lymphokin\u2010activated cells of patients with soft tissue sarcomas and melanomas in dependence on expression of MHC classes I and II antigenes","volume":"28","author":"Berezhnaya N. M.","year":"2006","journal-title":"Experimental Oncology"},{"key":"e_1_2_11_14_1","first-page":"1101","article-title":"MMP\u20102 expression in uveal melanoma: Differential activation status dictated by the cellular environment","volume":"11","author":"Berube M.","year":"2005","journal-title":"Molecular Vision"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20205"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031502\u20106"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(00)81235\u20100"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73020"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12041"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053970"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc40887b"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.034561"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.08.018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.10.797"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.045"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715932115"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010010\u20101378\u2010x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.057"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20108979\u20109_8"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.356"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10040"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17187"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000647"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006122"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11255"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016583\u20100"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.009"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.033"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2009.0606"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201037188\u20100"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603664"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201028515\u20106"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20101205\u20107_4"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.663110"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021207\u20102"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201012\u2010455"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.08.038"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000189571.84213.b0"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20320"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1535"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.95"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12274"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010006\u20109040\u20102"},{"issue":"7","key":"e_1_2_11_56_1","first-page":"2125","article-title":"Collective cell movement in primary melanoma explants: Plasticity of cell\u2010cell interaction, beta1\u2010integrin function, and migration strategies","volume":"62","author":"Hegerfeldt Y.","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201018\u20102409"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100215(20000701)87:1<12::aid\u2010ijc3>3.0.co;2\u2010a"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199805000\u201000017"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010006\u20100082\u20108"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4691"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4882"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.01.003"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192461099"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh194"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.036"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00839"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00036"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104302\u20100"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201017\u20100833"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.006"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000786\u2010z"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1333210"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101821\u20109"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202077"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.459"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201018\u20100193"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030380\u2010x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14343"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.050"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201008\u20103201"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010019\u20105606\u20104"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201081299\u20100"},{"issue":"12","key":"e_1_2_11_85_1","first-page":"2520","article-title":"Fate of melanoma cells entering the microcirculation: Over 80% survive and extravasate","volume":"55","author":"Koop S.","year":"1995","journal-title":"Cancer Research"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u2010148X.2011.00914.x"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100749.2001.140103.x"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2941"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.037"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.14440\/jbm.2020.323"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201010\u20100605"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20471"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.3791\/2937"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201036551\u20105"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.17.3757"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002714"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.913.65.3"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109440(10)63207\u20105"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2009.01273.x"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1376"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109440(10)65628\u20103"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7169"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.12732"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17038"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201018\u20101397"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2014.891677"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12498"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.001149"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033571"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201038603\u2010w"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201009\u20100650"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049452"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160378"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9207"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030881\u20109"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20714"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.11.021"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00326"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.11.002"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im2001s39"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201067492\u20107"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.031"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082492"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30684"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201018\u20100054"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201096707\u20108"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00107"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S297831"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216013110"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206693"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010019\u20100672\u20106"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8172"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922313117"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201010129\u2010z"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7659"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12303"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015546\u20109"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112510"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.3791\/62353"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201012\u20100563"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.10.009"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2018.07.010"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015170"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31559\u20109"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20101205\u20107_13"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390\u2010200508000\u201000001"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201016\u20100485"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006317125454"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130579"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1670019"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201006\u20100084"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.3.1.1"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04304"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051\u20101426\u20102\u20103"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2017.11.002"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206457"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025177\u20103"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101847\u20102"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201015\u20103384"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201017\u20100699"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010020\u201002029\u2010z"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010003863"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00184"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711741105"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102623\u2010z"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.2144\/04376ST02"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau7314"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107007\u201010\u201029"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2774"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010019\u201008143\u20108"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.131"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3839"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010016\u20100349\u20103"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.07.023"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010019\u20101138\u20107"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3055"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14023"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004584\u20106"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.002"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36670"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20182"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.006"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.004"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42358"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07\u20101606"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19103"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.05.014"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bav097"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.06.045"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201017\u20101371"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.07.15.500231"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010019\u20106344\u20103"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114552"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.13078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pcmr.13078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.13078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:49:31Z","timestamp":1692420571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.13078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":192,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/pcmr.13078"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.13078","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,7]]},"assertion":[{"value":"2022-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}