{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:36:31Z","timestamp":1785537391537,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA08748"],"award-info":[{"award-number":["P30 CA08748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the long\u2010term outcomes of anti\u2010PD\u20101 treated patients with melanoma beyond 5\u2009years, especially for patients treated off clinical trials. This retrospective cohort study includes patients with unresectable stage III\/IV nonuveal melanoma treated with anti\u2010PD\u20101 off\u2010trial at Memorial Sloan Kettering Cancer Center between 2014 and 2017 who survived at least 5\u2009years following their first anti\u2010PD\u20101 dose (<jats:italic>N<\/jats:italic>\u00a0=\u00a0139). We characterized overall survival (OS), melanoma\u2010specific survival (MSS) estimates, treatment\u2010free survival rates, and subsequent treatment courses. Median follow\u2010up among 5\u2010plus year survivors (<jats:italic>N<\/jats:italic>\u00a0=\u00a0125) was 78.4\u2009months (range 60.0\u201396.3). OS at year 7 (2\u2009years post 5\u2010year landmark) was 90.1% (95% CI: 83.0%\u201394.3%). Fourteen deaths occurred, seven due to melanoma. MSS at year 7 (2\u2009years post 5\u2010year landmark) was 95.0% (95% CI: 33.5%\u201395.2%). In patients who completed anti\u2010PD\u20101 based therapy and did not require subsequent treatment by 5\u2009years (<jats:italic>N<\/jats:italic>\u00a0=\u00a080), the probability of not requiring additional treatment for an additional 2\u2009years was 95.7% (95% CI: 91.0%\u2013100%). Patients treated with anti\u2010PD\u20101 regimens off clinical trials who survive at least 5\u2009years from initial anti\u2010PD\u20101 treatment can be reassured of their excellent long\u2010term prognosis, particularly if they did not require additional melanoma treatment during the first 5\u2009years.<\/jats:p>","DOI":"10.1111\/pcmr.13083","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T11:24:24Z","timestamp":1681212264000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Beyond the <scp>5\u2010year<\/scp> milestone: Long\u2010term survivorship of melanoma patients treated <scp>off\u2010trial<\/scp> with <scp>anti\u2010PD<\/scp>\u20101"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-7133","authenticated-orcid":false,"given":"Kimberly","family":"Loo","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Department of Internal Medicine New\u00a0York\u2010Presbyterian Hospital and Weill Cornell Medicine  New York City New\u00a0York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-0602","authenticated-orcid":false,"given":"Hannah L.","family":"Kalvin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Panageas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret K.","family":"Callahan","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Momtaz","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-4412","authenticated-orcid":false,"given":"Alexander N.","family":"Shoushtari","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jedd D.","family":"Wolchok","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Postow","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison Betof","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"},{"name":"Weill Cornell Medical College  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim\u20102020\u2010001650"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475715"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.9522"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz394.065"},{"key":"e_1_2_11_7_1","unstructured":"Robert C.(2021).7\u2010year follow\u2010up of KEYNOTE\u2010006: Pembrolizumab (pembro) versus ipilimumab (ipi) in advanced melanoma. Presented at: International Congress for the Society of Melanoma Research; October 31."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2736"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.2518"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109970"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02229"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.13083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:38:09Z","timestamp":1692560289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.13083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,11]]},"references-count":10,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/pcmr.13083"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.13083","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,11]]},"assertion":[{"value":"2022-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}