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In this pilot experimental study, we analyzed the expression in the peritumor subcutaneous adipose tissue of the most significant adipokines involved in the processes of carcinogenesis and metastasis in a population of melanoma patients and in two control groups composed of melanocytic nevi and epidermoid cysts, respectively. We correlated the results obtained with the main disease prognostic factors observing a statistically significant increase in the expression of PAI1, LEP, CXCL1, NAMPT, and TNF\u2010\u03b1 at the level of the peritumor tissue of the melanoma samples compared to the control groups and a correlation of the same with the histopathological prognostic factor of melanoma. Our preliminary study shows that the overexpression of PAI1, LEP, CXCL1, NAMPT, and TNF\u2010\u03b1 may contribute to the growth and to the local aggressiveness of cutaneous melanoma. It opens the hypothesis of a direct oncogenic role of subcutaneous adipose tissue and adipokines in the tumorigenesis of melanoma.<\/jats:p>","DOI":"10.1111\/pcmr.13103","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T08:40:30Z","timestamp":1687164030000},"page":"423-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Melanoma and subcutaneous adipose tissue: Role of peritumoral adipokines in disease characterization and prognosis"],"prefix":"10.1111","volume":"36","author":[{"given":"Elisa","family":"Molinelli","sequence":"first","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Macerata Hospital  Macerata 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