{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:33:24Z","timestamp":1782538404159,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucosal melanoma (MM) is a rare subtype of melanoma with an aggressive clinical course. In cutaneous melanoma (CM), the absence of pigmentation and presence of NRAS\/KRAS mutations are biomarkers indicating an aggressive clinical course with shorter overall survival. Similar data for MM are missing. We present the real\u2010world outcome data in a cohort of genotyped MM patients and assessed the prognostic relevance of pigmentation\u2010 and NRAS\/KRAS mutation status. We correlated pathological reports and clinical data with overall survival of patients with MM. Furthermore, we performed clinically integrated molecular genotyping and analyzed real world treatment regimens for covariates associated with clinical outcome. We identified 39 patients with available clinical and molecular data. Patients with amelanotic MM had a significantly shorter overall survival (<jats:italic>p<\/jats:italic>\u2009=\u2009.003). In addition, the presence of a NRAS or KRAS mutation was significantly associated with poor overall survival (NRAS or KRAS <jats:italic>p<\/jats:italic>\u2009=\u2009.024). Currently, it is unknown if the same prognostic relevance for the lack of pigmentation and RAS mutations in CM, exists in MM. Here we analyzed a cohort of MM for outcome measures and determined that two known prognostic biomarkers for CM are in fact novel prognosticators for MM.<\/jats:p>","DOI":"10.1111\/pcmr.13104","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T17:24:40Z","timestamp":1688145880000},"page":"378-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic biomarkers for survival in mucosal melanoma"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-3866","authenticated-orcid":false,"given":"Julia C.","family":"Thierauf","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Heidelberg University Hospital and Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Kaluziak","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Marine Science Center Northeastern University  Nahant Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Codd","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy N.","family":"Dybel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Center for Integrated Diagnostics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Jobbagy","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashi","family":"Purohit","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex A.","family":"Farahani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Center for Integrated Diagnostics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Dedeilia","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Naranbhai","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Massachusetts General Hospital Cancer Center  Boston Massachusetts USA"},{"name":"Center for the AIDS Programme of Research in South Africa  Durban South Africa"},{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai P.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-8165","authenticated-orcid":false,"given":"Adam S.","family":"Fisch","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Ritterhouse","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve M.","family":"Boland","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen K.","family":"Lennerz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Center for Integrated Diagnostics Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. John","family":"Iafrate","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12105\u2010021\u201001366\u2010W"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS12092362"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNONC.2022.06.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30180\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010158\u20104\u2010201302190\u201000009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE22071"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.03.042"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCITRANSLMED.ABD8636"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000035"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2021.702287"},{"issue":"8","key":"e_1_2_11_14_1","first-page":"739","article-title":"Primary mucosal melanomas: A comprehensive review","volume":"5","author":"Mihajlovic M.","year":"2012","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_11_15_1","unstructured":"Mucosal Melanoma of Head and Neck Staging. 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