{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:23:46Z","timestamp":1780079026454,"version":"3.54.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sentinel lymph node biopsy (SLNB) provides important prognostic information for early\u2010stage melanomas. However, statistics regarding the survival comparison between SLNB and nodal observation in Asia, where acral lentiginous melanoma (ALM) predominates, are limited. This study aimed to identify if SLNB offered survival benefits over nodal observation in early\u2010stage melanomas in Taiwan. The retrospective study included 227 patients who met the SLNB criteria according to the National Comprehensive Cancer Network guidelines and were treated at National Taiwan University Hospital from June 1997 to June 2021. Survival analysis was performed using Kaplan\u2013Meier curves and Cox proportional hazards regression models. Of the study population, ALM accounted for 73.1%; 161 patients (70.9%) underwent SLNB and 66 patients (29.1%) were under nodal observation. Multivariate analysis showed significantly improved melanoma\u2010specific survival (hazard ratio [HR], 0.6; <jats:italic>p<\/jats:italic>\u2009=\u2009.02) in the SLNB group. Among those who underwent completion lymph node dissection (CLND), the non\u2010sentinel node positivity rate was 44.4%. Immediate CLND resulted in significantly longer melanoma\u2010specific survival and distant\u2010metastasis\u2010free survival (DMFS) compared to nodal observation. (HR, 0.2; <jats:italic>p<\/jats:italic>\u2009=\u2009.01 for melanoma\u2010specific survival. HR, 0.3; <jats:italic>p<\/jats:italic>\u2009=\u2009.046 for DMFS). In conclusion, SLNB may provide survival benefits of cutaneous melanoma over nodal observation in the Taiwanese population.<\/jats:p>","DOI":"10.1111\/pcmr.13113","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T01:04:45Z","timestamp":1689815085000},"page":"522-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Survival benefit of sentinel lymph node biopsy in Asian melanoma patients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-3364","authenticated-orcid":false,"given":"Che\u2010Chia","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Medical Education National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-7496","authenticated-orcid":false,"given":"Yi\u2010Shuan","family":"Sheen","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2008.609"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"32","article-title":"Predictors of sentinel lymph node metastasis in melanoma","volume":"53","author":"Cadili A.","year":"2010","journal-title":"Canadian Journal of Surgery"},{"issue":"3","key":"e_1_2_8_4_1","first-page":"299","article-title":"Sentinel lymph node biopsy or nodal observation in melanoma: Study of an Italian series","volume":"148","author":"Calista D.","year":"2013","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"issue":"6","key":"e_1_2_8_5_1","first-page":"602","article-title":"Cutaneous melanoma: Taiwan experience and literature review","volume":"33","author":"Chang J. 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