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Hematoxylin and eosin (H&amp;E)\u2010stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma\u2010specific survival was calculated. Unpigmented melanomas (<jats:italic>n<\/jats:italic>\u2009=\u200999) had a melanoma\u2010specific survival of 67.7%, melanomas with moderate pigmentation (<jats:italic>n<\/jats:italic>\u2009=\u2009384) had a melanoma\u2010specific survival of 85.9%, and strongly pigmented melanomas (<jats:italic>n<\/jats:italic>\u2009=\u2009292) had a melanoma\u2010specific survival of 91.4% (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In an analysis of melanoma\u2010specific survival adjusted for pT stage and pigmentation, we found a nonsignificant impact of pigmentation abundance with a hazard ratio of 1.277 (<jats:italic>p<\/jats:italic>\u2009=\u2009.74). The study presented here provides evidence in a German cohort that patients with pigmented melanomas have a more favorable prognosis than those diagnosed with nonpigmented melanomas. Moreover, the abundance of pigmentation already seems to provide a first prognostic estimate. However, it does not appear to provide significant additional value for prognostic assessment according to the AJCC 2017 pT classification.<\/jats:p>","DOI":"10.1111\/pcmr.13114","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T07:20:28Z","timestamp":1689837628000},"page":"512-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histopathologic abundance of pigmentation correlates with disease\u2010specific survival in malignant melanoma but is not independent of current <scp>AJCC pT<\/scp> stage"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7040-4949","authenticated-orcid":false,"given":"Valentin","family":"Aebischer","sequence":"first","affiliation":[{"name":"Universit\u00e4ts\u2010Hautklinik, Eberhardt Karls Universit\u00e4t  T\u00fcbingen 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