{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:25:54Z","timestamp":1790270754330,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exosomes are involved in intercellular communication by transferring cargo between cells and altering the specific functions of the target cells. Recent studies have demonstrated the therapeutic effects of exosomes in several skin diseases. However, understanding of the effects of exosomes on anti\u2010pigmentation is limited. Therefore, we investigated whether BJ\u20105ta exosomes (BJ\u20105ta\u2010Ex) derived from human foreskin fibroblasts regulate melanogenesis and delineated the underlying mechanism. Interestingly, treatment with BJ\u20105ta\u2010Ex induced decreased melanin content, tyrosinase (TYR) activity, and expression of melanogenesis\u2010related genes, including microphthalmia\u2010related transcription factor (MITF), TYR, tyrosinase\u2010related protein\u20101 (TRP1), and tyrosinase\u2010related protein\u20102 (TRP2). In addition, BJ\u20105ta\u2010Ex downregulated the cAMP\/PKA and GSK\u20103\u03b2\/\u03b2\u2010catenin signaling pathways and upregulated the MAPK\/ERK signaling pathway. Notably, treatment with BJ\u20105ta\u2010Ex inhibited \u03b1\u2010melanocyte\u2010stimulating hormone\u2010induced melanosome transport and decreased the expression of key proteins involved in melanosome transport, namely, rab27a and melanophilin (MLPH). To further confirm the depigmenting effects of BJ\u20105ta\u2010Ex, we conducted experiments using a three\u2010dimensional reconstituted human full skin model and ultraviolet B (UVB)\u2010irradiated mouse model. Treatment with BJ\u20105ta\u2010Ex improved tissue brightness and reduced the distribution of melanosomes. In UVB\u2010irradiated mouse ears, BJ\u20105ta\u2010Ex reduced the number of active melanocytes and melanin granules. These results demonstrate that BJ\u20105ta\u2010Ex can be useful for the clinical treatment of hyperpigmentation disorders.<\/jats:p>","DOI":"10.1111\/pcmr.13135","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T01:23:43Z","timestamp":1695864223000},"page":"232-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010melanogenic effect of exosomes derived from human dermal fibroblasts (BJ\u20105ta\u2010Ex) in C57BL\/6 mice and B16F10 melanoma cells"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-2521","authenticated-orcid":false,"given":"Jung Min","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine Chung\u2010Ang University  Seoul South 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