{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:53:44Z","timestamp":1747187624371,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breslow thickness, ulceration, and mitotic rate are well\u2010known prognostic factors for sentinel lymph node (SLN) metastasis in cutaneous melanoma. We investigated risk factors, including especially the degree of pigmentation, for SLN metastasis in Korean melanoma patients. We enrolled 158, composed of Korean 107 acral and 51 non\u2010acral melanoma patients who underwent SLN biopsy. Clinicopathologic features such as Breslow thickness, ulceration, mitotic rate, and the degree of pigmentation were evaluated. The recurrence\u2010free survival (RFS) rate and date of recurrence were determined. Fifty\u2010four patients (34.2%) had a positive SLN biopsy result. In a multivariate analysis, Breslow thickness (odds ratio [OR] 1.93; 95% confidence interval [CI], 1.12\u20133.47; <jats:italic>p<\/jats:italic>\u2009=\u2009.022) and heavy pigmentation (OR 13.14; 95% CI, 2.96\u201395.20, <jats:italic>p<\/jats:italic>\u2009=\u2009.002) were associated with SLN metastasis. Positive SLN patients had a higher rate of loco\u2010regional and\/or distant recurrence (hazard ratio 6.32; 95% CI, 3.39\u201311.79; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Heavy pigmentation was associated with poor RFS. Heavy pigmentation is an independent predictor of SLN metastasis in both acral and non\u2010acral melanoma. Our results suggest the need for in\u2010depth SLN evaluation of cutaneous melanoma patients with heavy pigmentation and provide clinicians with important information for determining patient prognosis.<\/jats:p>","DOI":"10.1111\/pcmr.13153","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T06:11:10Z","timestamp":1701151870000},"page":"332-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for sentinel lymph node metastasis in Korean acral and non\u2010acral melanoma patients"],"prefix":"10.1111","volume":"37","author":[{"given":"Jee Yong","family":"Song","sequence":"first","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical School  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Jae","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chonnam National University Medical School  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Kyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chonnam National University Medical School  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Chonnam National University Medical School  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jeong","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology Chonnam National University Medical School  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-5831","authenticated-orcid":false,"given":"Sook Jung","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical School  Gwangju 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