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Using immunostaining studies, discovery\u2010stage RNA\u2010Seq analysis, and confirmatory in\u00a0situ hybridization, we analyzed paired biopsies collected from vitiligo lesions that did not repigment after 6\u2009months of NBUVB treatment (non\u2010responding) and compared them with repigmented (responding) lesions from the same patient. Non\u2010responding lesions exhibited acanthotic epidermis, had low number of total, proliferative, and differentiated melanocyte (MC) populations, and increased number of senescent keratinocytes (KCs) and of cytotoxic CD8+ T cells as compared with responding lesions. The abnormal response in the non\u2010responding lesions was driven by a dysregulated cAMP pathway and of upstream activator PDE4B, and of WNT\/\u03b2\u2010catenin repigmentation pathway. Vitiligo\u2010responding lesions expressed high levels of WNT10B ligand, a molecule that may prevent epidermal senescence induced by NBUVB, and that in cultured melanoblasts prevented the pro\u2010melanogenic effect of \u03b1\u2010MSH. Understanding the pathways that govern lack of NBUVB\u2010induced vitiligo repigmentation has a great promise in guiding the development of new therapeutic strategies for vitiligo.<\/jats:p>","DOI":"10.1111\/pcmr.13160","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:19:46Z","timestamp":1707718786000},"page":"378-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vitiligo non\u2010responding lesions to narrow band UVB have intriguing cellular and molecular abnormalities that may prevent epidermal repigmentation"],"prefix":"10.1111","volume":"37","author":[{"given":"Nathaniel B.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Steel","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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