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A large number of pigmentation genes associated with pigmentary disorders have been identified, many of them awaiting in\u00a0vivo confirmation. A more comprehensive understanding of the molecular basis of pigmentary disorders requires a vertebrate animal model where changes in pigmentation are easily observable in\u00a0vivo and can be combined to genomic modifications and gain\/loss\u2010of\u2010function tools. Here we present the amphibian <jats:italic>Xenopus<\/jats:italic> with its unique features that fulfill these requirements. Changes in pigmentation are particularly easy to score in <jats:italic>Xenopus<\/jats:italic> embryos, allowing whole\u2010organism based phenotypic screening. The development and behavior of <jats:italic>Xenopus<\/jats:italic> melanocytes closely mimic those observed in mammals. Interestingly, both <jats:italic>Xenopus<\/jats:italic> and mammalian skins exhibit comparable reactions to ultraviolet radiation. This review highlights how <jats:italic>Xenopus<\/jats:italic> constitutes an alternative and complementary model to the more commonly used mouse and zebrafish, contributing to the advancement of knowledge in melanocyte cell biology and related diseases.<\/jats:p>","DOI":"10.1111\/pcmr.13178","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T23:49:37Z","timestamp":1717804177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Xenopus<\/i> as a model system for studying pigmentation and pigmentary disorders"],"prefix":"10.1111","volume":"38","author":[{"given":"Joudi","family":"El Mir","sequence":"first","affiliation":[{"name":"University of Bordeaux, Inserm, BRIC, UMR 1312  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, BRIC, UMR 1312  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