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Upon change to BRAF\/MEK targeted therapy with nivolumab, a durable complete response was achieved and remains ongoing, off treatment, 7\u2009years from diagnosis. Management of symptomatic LMD remains a critical unmet clinical challenge, with limited clinical trial data. This exceptional case is instructive, as the first published case of the use of the triplet, and the first durable response with therapy discontinuation, in melanoma LMD. The triple\u2010drug regimen may be considered a viable option in fit patients. This case highlights the potential for long\u2010term disease control and the critical and urgent need to develop clinical trials inclusive of patients with LMD to define the best treatment strategies.<\/jats:p>","DOI":"10.1111\/pcmr.13179","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:09:08Z","timestamp":1720051748000},"page":"801-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Durable complete response in a patient with leptomeningeal melanoma after treatment with dabrafenib, trametinib, and nivolumab"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-3300","authenticated-orcid":false,"given":"Sarah E.","family":"Lochrin","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren 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