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To discover novel variants associated with freckles, we performed GWAS and meta\u2010analysis in 4813 Chinese individuals. We conducted GWAS and meta\u2010analysis of two cohorts: 197 patients and 1603 controls (Cohort I), and 336 patients and 2677 controls (Cohort II), both from China. Then we performed linkage disequilibrium (LD) analysis, eQTL study, and enrichment analysis with association results for functional implications. Finally, we discovered 59 new SNPs and 13 novel susceptibility genes associated with freckles (P<jats:sub>meta<\/jats:sub>\u2009&lt;5\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>), which has enriched the genetic research on freckles.<\/jats:p>","DOI":"10.1111\/pcmr.13183","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T11:54:16Z","timestamp":1720266856000},"page":"808-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome wide association study and meta\u2010analysis identified multiple new risk loci for freckles in 4813 Chinese individuals"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1855-432X","authenticated-orcid":false,"given":"Sihan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of 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