{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:46:00Z","timestamp":1790217960101,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016087"],"award-info":[{"award-number":["P30CA016087"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U54CA263001"],"award-info":[{"award-number":["U54CA263001"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA269286"],"award-info":[{"award-number":["R01CA269286"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201020\u2010MRP\u2010TSA"],"award-info":[{"award-number":["W81XWH\u201020\u2010MRP\u2010TSA"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>As efforts to study the mechanisms of melanoma metastasis and novel therapeutic approaches multiply, researchers need accurate, high\u2010throughput methods to evaluate the effects on tumor burden resulting from specific interventions. We show that automated quantification of tumor content from whole slide images is a compelling solution to assess in\u00a0vivo experiments. In order to increase the outflow of data collection from preclinical studies, we assembled a large dataset with annotations and trained a deep neural network for the quantitative analysis of melanoma tumor content on histopathological sections of murine models. After assessing its performance in segmenting these images, the tool obtained consistent results with an orthogonal method (bioluminescence) of measuring metastasis in an experimental setting. This AI\u2010based algorithm, made freely available to academic laboratories through a web\u2010interface called MetFinder, promises to become an asset for melanoma researchers and pathologists interested in accurate, quantitative assessment of metastasis burden.<\/jats:p>","DOI":"10.1111\/pcmr.13195","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T06:48:33Z","timestamp":1725950913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MetFinder<\/scp>: A Tool for Automated Quantitation of Metastatic Burden in Histological Sections From Preclinical\u00a0Models"],"prefix":"10.1111","volume":"38","author":[{"given":"Alcida","family":"Karz","sequence":"first","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Coudray","sequence":"additional","affiliation":[{"name":"Applied Bioinformatics Laboratories NYU Langone Health  New York New York USA"},{"name":"Department of Cell Biology NYU School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristyn","family":"Galbraith","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Jour","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman Alberto Sorin","family":"Shadaloey","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-4769","authenticated-orcid":false,"given":"Nicole","family":"Eskow","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Rubanov","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Moubarak","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Baptiste","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Levinson","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Mezzano","sequence":"additional","affiliation":[{"name":"Experimental Pathology Research Laboratory, Division of Advanced Research Technologies NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Alu","sequence":"additional","affiliation":[{"name":"Experimental Pathology Research Laboratory, Division of Advanced Research Technologies NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Loomis","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Experimental Pathology Research Laboratory, Division of Advanced Research Technologies NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lima","sequence":"additional","affiliation":[{"name":"Research Software Engineering Core, Medical Center Information Technology Department NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Rubens","sequence":"additional","affiliation":[{"name":"Research Software Engineering Core, Medical Center Information Technology Department NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Jilaveanu","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis","family":"Tsirigos","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Applied Bioinformatics Laboratories NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hernando","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"},{"name":"Interdisciplinary Melanoma Cooperative Group Perlmutter Cancer Center, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.05.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585\u2010020\u201010020\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpi.2022.100007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"Bankhead P. M. B.Loughrey J. A.Fern\u00e1ndez et\u00a0al. n.d.\u201cQuPath: Open Source Software for Digital Pathology Image Analysis.\u201dhttps:\/\/doi.org\/10.1101\/099796.","DOI":"10.1101\/099796"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2020050597"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18268"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.3.121806.154244"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100177\u20105"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201008\u20100041"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036967\u20102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u2010148x.2012.00994.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180540"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001098\u20104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/813543"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.11.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4391"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202708"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201020\u20102415"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010020\u20100087\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.09.034"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201021\u20101006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.ccr\u201019\u20101495"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2021.130"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006689719505"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpi.jpi_5_20"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.3.1225"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374\u2010019\u20100257\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi7127"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201019\u20101228"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12155"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.01.011"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100818\u20103"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00297"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100044\u20104"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623320926478"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1109\/38.946629"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000929\u20109"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201016\u20100485"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3791\/63186"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201053911\u2010x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.134"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.3.7.1163"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot078253"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","unstructured":"Szegedy C. V.Vanhoucke S.Ioffe J.Shlens andZ.Wojna.2016.\u201cRethinking the Inception Architecture for Computer Vision.\u201d 2016 IEEE Conference on Computer Vision and Pattern Recognition CVPR 2016 Las Vegas June 27\u201330 2016 2818\u20132826.https:\/\/doi.org\/10.1109\/CVPR.2016.308.","DOI":"10.1109\/CVPR.2016.308"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.040"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012\u20100561\u2010CP"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021674\u20107"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010020\u201000750\u20106"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201023937\u20104_14"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101576\u20106"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201019\u20100270"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.13195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:29:39Z","timestamp":1758724179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.13195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/pcmr.13195"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.13195","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13195"}}