{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T02:09:19Z","timestamp":1775700559380,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Melanoma is the most aggressive and deadly form of skin cancer that arises from the transformation of melanocytes, the pigment producing cells of the skin. In the year 2024 there will be approximately 10,000 new cases of melanoma diagnosed and approximately 8,000 deaths attributed to melanoma in the United States. In this study we treated a group of male and female transgenic mice that spontaneously develop metastatic melanoma, TGS, with a G\u2010protein\u2010coupled estrogen receptor agonist LNS8801 to assess the efficacy on disease progression. A second group of male and female TGS mice was also exposed to UVB irradiation to mimic exposure to sunlight. Over the course of the 32\u2010week experiment, visible images were taken by the small animal imaging IVIS system to track tumor progression, and blood and tissue samples were collected for molecular analyses. Results showed that sex\u2010biased effects were observed in the efficacy of LNS8801 and that LNS8801 shows a UV\u2010protective influence in both male and female TGS mice.<\/jats:p>","DOI":"10.1111\/pcmr.13197","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T06:40:22Z","timestamp":1726468822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An In\u00a0Vivo Study of <scp>LNS8801<\/scp>, a <scp>GPER<\/scp> Agonist, in a Spontaneous Melanoma\u2010Prone Mouse Model, <scp>TGS<\/scp>"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1979-0167","authenticated-orcid":false,"given":"Christina","family":"Marinaro","sequence":"first","affiliation":[{"name":"Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy Rutgers University, The State University of New Jersey  New Brunswick New Jersey USA"},{"name":"U.S. Department of Veterans Affairs  East Orange New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sauer","sequence":"additional","affiliation":[{"name":"Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy Rutgers University, The State University of New Jersey  New Brunswick New Jersey USA"},{"name":"Rowan\u2010Virtua School of Osteopathic Medicine Rowan University  Stratford New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Natale","sequence":"additional","affiliation":[{"name":"Linnaeus Therapeutics Inc.  Haddonfield New Jersey USA"},{"name":"Department of Dermatology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Ridky","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-5081","authenticated-orcid":false,"given":"Suzie","family":"Chen","sequence":"additional","affiliation":[{"name":"Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy Rutgers University, The State University of New Jersey  New Brunswick New Jersey USA"},{"name":"U.S. Department of Veterans Affairs  East Orange New Jersey USA"},{"name":"Rutgers Cancer Institute of New Jersey  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1999.tb08669.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90205-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.08.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio775"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102567.2011.03471.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.20"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.1.14292"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.03.1664"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/372413a0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.16.1.0758"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2565"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026\u2010009\u20108150\u20105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2009.03.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3711"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.5.2783"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00182"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.am2021\u20101282"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31770"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1148"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106943"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.09.017"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.09.2235"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.2.790"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.9543"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3107127"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/350516a0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010014\u20101598\u20102"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195904162601601"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3097"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.1998.00133.x"}],"container-title":["Pigment Cell &amp; 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