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Multiple risk factors, particularly immune\u2010related inflammatory factors, are involved in the disappearance of melanocytes. LL37 is a classic damage\u2010associated molecular pattern molecule that is involved in the development of various autoimmune diseases. An enhanced expression of LL37 in vitiligo is known; however, the exact role of LL37 in melanocyte loss has not yet been elucidated. In the present study, we detected increased LL37 expression in vitiligo serum and lesions. Furthermore, we confirmed that cultured keratinocytes released LL37 after treatment with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Moreover, the LL37\u2010DNA complex enhanced the secretion of CXCL9, CXCL10, and CXCL16 from keratinocytes via the TLR9\u2010MyD88 signaling pathway and facilitated the migration of CD8<jats:sup>+<\/jats:sup> T cells. Altogether, our study demonstrates that LL37 released from keratinocytes binds to DNA and contributes to melanocyte destruction under oxidative stress\u2010induced autoimmunity in vitiligo.<\/jats:p>","DOI":"10.1111\/pcmr.13202","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:00:01Z","timestamp":1727676001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>LL37<\/scp>\u2010<scp>DNA<\/scp> Complex Drives Vitiligo Progression Through <scp>TLR9<\/scp>\u2010<scp>MyD88<\/scp> Signaling Pathways"],"prefix":"10.1111","volume":"38","author":[{"given":"Jingying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical Center Hospital of Qionglai City  Qionglai Sichuan China"},{"name":"Department of Dermatology The Affiliated Hospital of Southwest Medical University  Luzhou Sichuan 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