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This study was designed to explore the anti\u2010melanogenic and anti\u2010inflammatory effects of Bay 11\u20107082, an NF\u2010\u03baB inhibitor, using small\u2010molecule screening, to determine its potential application for PIH prevention. The molecular mechanisms were investigated in\u00a0vitro and ex\u00a0vivo in epidermis\u2010humanized mice using melanin content, RT\u2010PCR, and immunoblotting. Bay 11\u20107082 suppressed proinflammatory cytokines and ameliorated 2,4\u2010dinitrofluorobenzene (DNFB)\u2010induced contact dermatitis on day 15. The suppression of melanin synthesis by Bay 11\u20107082 was attributed to the reduction of MITF, which was induced by extracellular signal\u2010regulated kinase activation. Bay 11\u20107082 reduced epidermal melanin accumulation in UVB\u2010stimulated ex\u00a0vivo human epidermis as well as in the ear and tail skin of K14\u2010stem cell factor (SCF) transgenic mice. Topical administration of Bay 11\u20107082 improved PIH on day 35 in the post\u2010DNFB dorsal skin of K14\u2010SCF transgenic mice. In conclusion, Bay 11\u20107082 can be considered a promising candidate for the development of a preventive topical agent for PIH.<\/jats:p>","DOI":"10.1111\/pcmr.13207","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:18:55Z","timestamp":1730074735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bay 11\u20107082, an <scp>NF<\/scp>\u2010<scp>\u03baB<\/scp> Inhibitor, Prevents Post\u2010Inflammatory Hyperpigmentation Through Inhibition of Inflammation and Melanogenesis"],"prefix":"10.1111","volume":"38","author":[{"given":"Juwon","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Medical Science University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-4166","authenticated-orcid":false,"given":"Ik Jun","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoyong","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Medical Science University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Medical Science University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hyun","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Medical Science University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-5223","authenticated-orcid":false,"given":"Youngsup","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Brain Science, Brain Korea 21 Project University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.036"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"18","article-title":"Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients With Acne Vulgaris","volume":"10","author":"Darji K.","year":"2017","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"7","key":"e_1_2_9_4_1","first-page":"20","article-title":"Postinflammatory Hyperpigmentation: A Review of the Epidemiology, Clinical Features, and Treatment Options in Skin of Color","volume":"3","author":"Davis E. 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