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In melanoma, lipid droplet formation has been linked to tumor progression and metastasis, but it is unknown whether lipid droplet proteins play a role. To address this, we performed proteomic analysis of the lipid droplet envelope in melanoma. We found that lipid droplet proteins were differentially enriched in distinct melanoma states; from melanocytic to undifferentiated. DHRS3, which converts all\u2010trans\u2010retinal to all\u2010trans\u2010retinol, is upregulated in the MITF\n                    <jats:sup>LO<\/jats:sup>\n                    \/undifferentiated\/neural crest\u2010like melanoma cell state and reduced in the MITF\n                    <jats:sup>HI<\/jats:sup>\n                    \/melanocytic state. Increased DHRS3 expression is sufficient to drive MITF\n                    <jats:sup>HI<\/jats:sup>\n                    \/melanocytic cells to a more undifferentiated\/invasive state. These changes are due to retinoic acid\u2010mediated regulation of melanocytic genes. 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