{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:24:19Z","timestamp":1784291059561,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vitiligo pathogenesis is complex. There is some evidence in support of the neurohormonal pathways involved. Although considered a nonpruritic condition, some patients may experience itching, which can occur ahead of the appearance of the patches. We aimed to assess sensory symptoms in active and stable vitiligo patients and to measure 3 neuropeptide expressions in their lesional skin (neuropeptide Y [NPY], calcitonin gene\u2013related peptide [CGRP], and nerve growth factors [NGF]) to correlate neuropeptide levels and sensory symptoms, with vitiligo activity. This case\u2013control study included 85 patients, aged 18\u2009years and older, analyzed into active or stable vitiligo groups. Patients were screened for itching or other abnormal neurological sensations such as paresthesia and numbness. The Vitiligo Disease Activity Score, Vitiligo Signs of Activity Score, and dermoscopic score were performed to assess disease activity. Three neuropeptides were quantified by enzyme\u2010linked immunosorbent assay in skin biopsies from the edge of vitiligo lesions. A normal control group was also included. Results showed that 24.7% of patients had sensory symptoms: itching (18.8%), paresthesia (2.4%), and numbness (3.5%). The NGF, CGRP, and NPY levels were significantly higher in skin of normal controls compared to stable and active vitiligo patients. They were lowest in active vitiligo skin (<jats:italic>p<\/jats:italic>\u2009=\u20090.001, 0.016, and 0.01, respectively). NGF was the most relevant neuropeptide to vitiligo activity and sensory manifestations. In conclusion, almost one\u2010third of the patients with active vitiligo reported sensory symptoms, predominantly itching, thus sensory manifestations may suggest a prodroma of activity and could be included in the screening tools for vitiligo activity.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link> (NCT05390164).<\/jats:p>","DOI":"10.1111\/pcmr.13223","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T10:13:54Z","timestamp":1737972834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sensory Symptoms as an Early Manifestation of Active Vitiligo: A Case\u2013Control Clinical and Molecular Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-8456","authenticated-orcid":false,"given":"Hagar","family":"El Sayed","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"El Wakeel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Nour","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham","family":"Mohyeeldeen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Hafez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365\u20104362.2003.01936.X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101265"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102133.1994.TB08486.X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054910"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.1959.50"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5826\/DPC.0404A18"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.12998\/WJCC.V3.I3.221"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHDERM.140.6.677"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0227909"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14922"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/IJD.13795"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0107020"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20100625.1993.TB00023.X"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHDERM.1958.01560090088018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_75_18"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700429"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.00026.2005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJD.IJD_822_19"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/HUMU.21299"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5617838"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.18950"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.18950"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","unstructured":"Yu R. Y.Huang X.Zhang andY.Zhou.2012. \u201cPotential Role of Neurogenic Inflammatory Factors in the Pathogenesis of Vitiligo.\u201d 16 no. 4: 230\u2013244.https:\/\/Doi.Org\/10.1177\/120347541201600404.","DOI":"10.1177\/120347541201600404"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.13223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:29:03Z","timestamp":1758724143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.13223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/pcmr.13223"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.13223","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13223"}}