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Certain bacteria like <jats:italic>Staphylococcus<\/jats:italic> and <jats:italic>Veillonella<\/jats:italic> are important for wound healing, while <jats:italic>Cutibacterium acnes<\/jats:italic> can play a role in dermatoses. UV radiation alters the skin microbiome, originates a \u201cUV\u2010resistome\u201d and can lead to skin cancer initiation. Specifically, <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus epidermidis<\/jats:italic><\/jats:styled-content> has shown protective effects against skin cancer, whereas <jats:italic>Cutibacterium acnes<\/jats:italic> can induce apoptosis in melanocytes postirradiation. The microbiome also interacts with melanoma treatment, affecting responses to immune checkpoint inhibitors. Strategies like bacteriotherapy, involving the manipulation of the gut microbiome but also the skin microbiome (with the gut\u2013skin axis or through topical treatment) could improve treatment outcomes and show promise in melanoma therapy. Understanding the complex interplay between the skin microbiome, UV exposure, and melanoma development is crucial for developing personalized therapeutic approaches. Investigation into the skin microbiome and its potential role in melanoma progression continues to be an exciting area of research with implications for future therapeutic interventions.<\/jats:p>","DOI":"10.1111\/pcmr.13224","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T10:03:40Z","timestamp":1741255420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Skin Microbiome: A New Key Player in Melanoma, From Onset to Metastatic Stage"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-7888","authenticated-orcid":false,"given":"Jean\u2010Matthieu","family":"L'Orphelin","sequence":"first","affiliation":[{"name":"Unicaen, Inserm U1086 Anticipe Normandie Univ  Caen France"},{"name":"Department of Dermatology Caen\u2010Normandy University Hospital  Caen 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