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This systematic review investigates the association between beta\u2010blocker use and survival outcomes in cutaneous melanoma patients. We reviewed 12 studies with 21,582 patients in a network meta\u2010analysis and found a benefit between beta\u2010blocker use and disease\u2010free survival but no other significant association for melanoma\u2010specific or overall survival. However, some evidence suggests that pan\u2010selective beta\u2010blockers, rather than cardio\u2010selective ones, may have a protective effect. We conclude that the current evidence is insufficient to recommend beta\u2010blockers for melanoma treatment but suggest further research focusing on pan\u2010selective beta\u2010blockers to clarify their potential benefits.<\/jats:p>","DOI":"10.1111\/pcmr.13225","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:25:23Z","timestamp":1736771123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Beta\u2010Blockers and Cutaneous Melanoma Outcomes: A Systematic Review and Random\u2010Effects Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-4109","authenticated-orcid":false,"given":"Nicholas M.","family":"Muller","sequence":"first","affiliation":[{"name":"Dermatology Research Centre, Frazer Institute The University of Queensland  Brisbane Australia"},{"name":"Department of Dermatology Princess Alexandra Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-1378","authenticated-orcid":false,"given":"Samuel X.","family":"Tan","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, Frazer Institute The University of Queensland  Brisbane Australia"},{"name":"Department of Dermatology Princess Alexandra Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9857-774X","authenticated-orcid":false,"given":"Nisal","family":"Vipulaguna","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, Frazer Institute The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-3436","authenticated-orcid":false,"given":"Chenhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, Frazer Institute The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8007-4816","authenticated-orcid":false,"given":"Maria Celia B.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre, Frazer Institute The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-561X","authenticated-orcid":false,"given":"H. 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