{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:44:32Z","timestamp":1787600672640,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373498"],"award-info":[{"award-number":["82373498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073456"],"award-info":[{"award-number":["82073456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003352"],"award-info":[{"award-number":["82003352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Childhood vitiligo, distinct from its adult counterpart, presents unique treatment challenges. Glycyrrhizin inhibits the release of high\u2010mobility group box\u00a01 (HMGB1) protein from keratinocytes, preventing melanocyte apoptosis and autophagy. Furthermore, the orally administered compound glycyrrhizin (OCG) effectively treats various autoimmune disorders, demonstrating long\u2010term efficacy, safety, and tolerability. This study compared the efficacy of OCG and oral prednisone (OP), followed by phototherapy, in patients with progressive childhood vitiligo at 52\u2009weeks' follow\u2010up. Fifty children with vitiligo were randomized into two groups according to treatment: OCG (50\u2013150\u2009mg\/day) followed by phototherapy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200925) and OP (5\u201310\u2009mg\/day) followed by phototherapy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200925). At Week 24, a halt in disease progression (HDP) was observed in 20 (80%) patients in the OCG group and 21 (84%) in the OP group, with no significant difference (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.99)\n                    <jats:italic>.<\/jats:italic>\n                    However, the mean time to achieve HDP was significantly shorter in the OP group than in the OCG group (14.73\u2009\u00b1\u20094.84 vs. 19.13\u2009\u00b1\u20094.82\u2009weeks;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). In addition, serum HMGB1 concentrations were significantly reduced after treatment with OCG at Week 24 (3.02\u2009\u00b1\u20090.83 vs. 0.95\u2009\u00b1\u20090.36\u2009ng\/mL [\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01]; OP, 2.79\u2009\u00b1\u20090.16 vs. 1.03\u2009\u00b1\u20090.34\u2009ng\/mL [\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01]). The decline in Vitiligo Area Scoring Index (VASI) score at the end of follow\u2010up (i.e., Week 52) did not show a statistically significant difference between the OCG and OP groups (52.31%\u2009\u00b1\u200914.86% vs. 55.71%\u2009\u00b1\u200921.23%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.55). The therapeutic response of the clinical markers of progression was good and comparable between the OCG and OP groups. OCG demonstrated similar efficacy to OP followed by phototherapy in controlling disease activity and promoting repigmentation in children with vitiligo at 52\u2009weeks of follow\u2010up.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ChiCTR2400086844\n                  <\/jats:p>","DOI":"10.1111\/pcmr.13226","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:39:17Z","timestamp":1739777957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness and Safety of Oral Compound Glycyrrhizin Followed by Phototherapy for the Treatment of Progressive Vitiligo in Children"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2259-0817","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhou","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8410-667X","authenticated-orcid":false,"given":"Yijian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-3962","authenticated-orcid":false,"given":"Leihong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2362"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021624"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.4867"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13451"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4126"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.02.010"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2007.04.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70119-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15877"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.4090"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2023.12.008"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106138"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035533"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.22.150"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15151"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13432"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439563"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2023.2213887"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13328"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.01.038"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.108040"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14645"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2007.03.007"},{"key":"e_1_2_12_25_1","first-page":"253","article-title":"Glycyrrhizin Protects Human Melanocytes From H2O2\u2010Induced Oxidative Damage via the Nrf2\u2010Dependent Induction of HO\u20101","volume":"44","author":"Mou K.","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20165354"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.05.038"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.09.051"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.010"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00430-0"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90133-6"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-021-00421-z"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.048"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.120.10_849"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.125479"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.021"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11111.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.04.029"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1973039"},{"key":"e_1_2_12_41_1","first-page":"16266","article-title":"Glycyrrhizin Combined With Acitretin Improve Clinical Symptom of Psoriasis via Reducing Th17 Cell Differentiation and Related Serum Cytokine Concentrations","volume":"8","author":"Wu W. Z.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-012-1173-0"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1254605"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4483"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.13226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T15:00:49Z","timestamp":1743346849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.13226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/pcmr.13226"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.13226","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13226"}}