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It has emerged as a first\u2010line treatment option for metastatic melanoma. By targeting checkpoint proteins such as programmed cell death\u2010ligand 1 (PD\u2010L1) and cytotoxic T\u2010lymphocyte associated protein 4 (CTLA\u20104), ICI therapy activates the immune system, enhancing its ability to combat cancer cells, leading to long\u2010term efficacy and potential cures in some patients. However, ICI therapy is not universally effective. Resistance and adverse reactions of ICI therapy occur in some patients. The identification of systematic biomarkers from blood tests may offer a rapid and efficient means to assess patient responsiveness to ICI therapy, as well as the risk of developing immune\u2010related adverse events (irAEs), to facilitate individualized patient selection. This article provides a comprehensive literature review of systemic biomarkers used in melanoma patients receiving ICI therapy. 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