{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:07:37Z","timestamp":1764151657220,"version":"3.46.0"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HP23C0146"],"award-info":[{"award-number":["HP23C0146"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cellular senescence is associated with altered lipid metabolism, including increased cellular lipid uptake, upregulated lipid biosynthesis, and deregulated lipid breakdown. Previous studies have reported that carnitine palmitoyltransferase (CPT), the rate\u2010limiting enzyme in fatty acid oxidation that catalyzes the conversion of acyl\u2010CoA to acylcarnitine, is involved in various senescence\u2010related diseases. Although solar lentigo (SL) is an age\u2010related pigmentary disorder characterized by the accumulation of senescent cells, its role in metabolic dysregulation has rarely been investigated. Integrated transcriptomic profiling of SL skin samples, combining mRNA sequencing, differential gene expression, pathway enrichment analyses, metabolic flux simulations, and protein\u2013protein interaction analysis, was conducted to demonstrate the molecular alterations in SL compared to perilesional normal skin. We found transcriptomic alterations in mitochondrial energy metabolism\u2010associated genes. Metabolic flux simulations revealed that carnitine\u2010associated reactions involved in fatty acid oxidation were upregulated. Using a multi\u2010omics approach,\n                    <jats:italic>CPT1B<\/jats:italic>\n                    was selected as a potential marker for SL. Using a zebrafish model,\n                    <jats:italic>CPT1B<\/jats:italic>\n                    was implicated in melanogenesis.\n                    <jats:italic>CPT1B<\/jats:italic>\n                    \u2010mediated metabolic alteration is a key driver of SL pathogenesis. Targeting\n                    <jats:italic>CPT1B<\/jats:italic>\n                    and the associated lipid metabolism pathways is a novel therapeutic approach for managing SL and age\u2010related pigmentation disorders.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.70063","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:56:39Z","timestamp":1761656199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CPT1B<\/scp>\n                    \u2010Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo"],"prefix":"10.1111","volume":"38","author":[{"given":"Yueun","family":"Choi","sequence":"first","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Biomedical Science and Technology Graduate School, Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2864-7996","authenticated-orcid":false,"given":"Uijeong","family":"Nam","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Biomedical Science and Technology Graduate School, Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4032-5369","authenticated-orcid":false,"given":"Jihan","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0066-5390","authenticated-orcid":false,"given":"Soo\u2010Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Division of Nephrology Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanseul","family":"Cho","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seoyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8789-575X","authenticated-orcid":false,"given":"Sanghyeon","family":"Yu","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Biomedical Science and Technology Graduate School, Kyung Hee University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Tourism &amp; Wellness Hankuk University of Foreign Studies  Yongin\u2010si Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae\u2010Na","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University Hospital at Gangdong Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4443-4161","authenticated-orcid":false,"given":"Bark\u2010Lynn","family":"Lew","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University Hospital at Gangdong Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-2390","authenticated-orcid":false,"given":"Yoonsung","family":"Lee","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Biomedical Science and Technology Graduate School, Kyung Hee University  Seoul Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-9829","authenticated-orcid":false,"given":"Man S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational\u2010Transdisciplinary Research Center Clinical Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University  Seoul Korea"},{"name":"Department of Biomedical Science and Technology Graduate School, Kyung Hee University  Seoul Korea"},{"name":"Department of Medicine Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-5725","authenticated-orcid":false,"given":"Soon\u2010Hyo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University Hospital at Gangdong Kyung Hee University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201037750\u20105"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201020\u20100329"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313701200"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2007.07830.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512002656"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1656"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.095"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1983.63.4.1420"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4072"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201057948\u20105"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X9700200201"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09806"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040880"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201592862"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.002"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20100509\u20107\u201074"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101550\u20100"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013713905833"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.75"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.10.016"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.01.006"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq1533"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2010.01209.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.5.626"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010021\u201001045\u20109"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2018.03.014"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010111315\u2010125134"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710073"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073973"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2022.111688"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.2001.01296.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.02.002"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155\u20106156.1000361"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.016"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.120386"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004321"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2010.09946.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.01.007"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202100207"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.06.006"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1198607"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.05.018"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123729"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.987"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.095"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100749.2004.00189.x"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.132"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.19800"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8mo00099a"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004808"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2011.04223.x"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12621"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001634"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.782445"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI92513"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.018"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.06.003"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26975"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.16288\/j.yczz.22\u2010187"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102294"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21665"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.70063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T09:31:53Z","timestamp":1764149513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.70063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/pcmr.70063"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.70063","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"type":"print","value":"1755-1471"},{"type":"electronic","value":"1755-148X"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70063"}}