{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:32:20Z","timestamp":1793831540614,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA014089"],"award-info":[{"award-number":["P30CA014089"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR0001301"],"award-info":[{"award-number":["UL1TR0001301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001855"],"award-info":[{"award-number":["UL1TR001855"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>While prior studies have described the development of vitiligo and alopecia among patients with metastatic melanoma undergoing cancer immunotherapy, there are scant reports of secondary poliosis. Here we detail a case series of patients with melanoma who developed poliosis secondary to cancer immunotherapy. A clinical database of melanoma patients treated at the University of Southern California, Norris Comprehensive Cancer Center, from 2018 to 2023 was reviewed to identify patients who developed poliosis during cancer immunotherapy treatment. Patients with both cutaneous and non\u2010cutaneous melanoma (acral and uveal) were included. Cancer immunotherapies included checkpoint inhibitors, bispecifics, and tumor infiltrating lymphocyte (TIL) therapy. Patient characteristics, tumor features (histology, stage), treatment variables, and clinical outcomes were collected for all patients. Immunotherapy\u2010related side effects, including poliosis, were recorded. A total of 10 melanoma patients with poliosis were identified, including 5 women; 8 had stage IV disease. The median duration of immunotherapy treatment was 20\u2009months (range 10\u201346). Median onset of poliosis was 4\u2009months (range 2\u201312). Amongst the 10 patients, 9 (90%) remain in continued response to treatment without disease progression at this time. This case series describes 10 melanoma patients who developed poliosis while undergoing immunotherapy, all of whom developed clinical benefit from treatment. This cohort included patients with rare and challenging melanoma subtypes, e.g., acral lentiginous and uveal melanoma. The development of poliosis may portend a positive clinical benefit from these immunotherapy treatments. Further research is necessary to elucidate the underlying mechanisms of immune\u2010mediated melanocyte destruction and depigmentation in melanoma patients receiving immunotherapy.<\/jats:p>","DOI":"10.1111\/pcmr.70089","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:59:37Z","timestamp":1779692377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of Poliosis in Patients Treated With Immunotherapy for Metastatic Cutaneous and Non\u2010Cutaneous Melanoma"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6686-9971","authenticated-orcid":false,"given":"Kimberly","family":"Smart","sequence":"first","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-9967","authenticated-orcid":false,"given":"Ivan","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse L.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, USC Roski Eye Institute and Children's Hospital Los Angeles, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Terando","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Cedars\u2010Sinai Health System  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Worswick","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7060-5123","authenticated-orcid":false,"given":"Gino K.","family":"In","sequence":"additional","affiliation":[{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Division of Oncology, University of Southern California Norris Comprehensive Cancer Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.302"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.01.056"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17215"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100799"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.2.178"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.7.1006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690170122027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001451"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rceng.2018.10.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100064"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/immuno2020020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525001113"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22071"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae427"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.038"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2707"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701183"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3209023902"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590200034006"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003951"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1310"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010016\u20100412\u20104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2011.04914.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.033"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701709"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01517212"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001798"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102019\u2010000331"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.08.030"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103485"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552231154460"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201022\u20100603"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(81)70051\u20103"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.5070\/D37SN7H2J7"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp325"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.05.042"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06887"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2016.02.001"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30259"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.022"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640150075022"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.03.036"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.4756"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14678"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.251"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.12.004"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12523"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15237"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.70089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pcmr.70089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.70089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:48:42Z","timestamp":1779943722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.70089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pcmr.70089"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.70089","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70089"}}