{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:47:40Z","timestamp":1785818860946,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2110675"],"award-info":[{"award-number":["W81XWH2110675"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012643","name":"Ohio Lions Eye Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2P30CA016058\u201040"],"award-info":[{"award-number":["2P30CA016058\u201040"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["8UL1TR000090\u201005"],"award-info":[{"award-number":["8UL1TR000090\u201005"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY032857"],"award-info":[{"award-number":["P30EY032857"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Germline genetic testing is increasingly incorporated into the care of patients with uveal melanoma, yet optimal testing strategies remain unclear. This study aimed to evaluate the outcome of germline clinical genetic testing in uveal melanoma (UM) patients who met the National Comprehensive Cancer Network (NCCN) guidelines for genetic testing. A retrospective chart review was conducted on UM patients seen in The Ohio State University Cancer Genetics Clinic between 5\/1\/2021 and 9\/19\/2025. Seventy individuals underwent clinical genetic testing, primarily via large multigene panels. Ten UM patients, including two related individuals, had pathogenic or likely pathogenic (P\/LP) variants in known cancer genes (\n                    <jats:italic>BAP1, BRCA1, BRCA2, MBD4, MUTYH, POT1, XRCC2<\/jats:italic>\n                    ). Among unrelated individuals, the positive rate was 13% (8\/69). Excluding carrier genes, the rate was 10.1% (7\/69). Eight patients would have been missed if only tested for\n                    <jats:italic>BAP1<\/jats:italic>\n                    per American Society of Clinical Oncology (ASCO) 2024 recommendations. There was no association between tumor size, stage, and germline P\/LP variants. In summary, NCCN guidelines are useful in the prioritization of UM patients for genetic testing. Additionally, these findings support genetic counseling for multigene panel testing in high\u2010risk uveal melanoma patients. Further studies of the impact of germline variants on UM disease outcome are warranted.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.70108","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:34:07Z","timestamp":1783492447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Multigene Panel Testing in High\u2010Risk Uveal Melanoma Patients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-5331","authenticated-orcid":false,"given":"Lindsey","family":"Byrne","sequence":"first","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Gray","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Department of Ophthalmology and Visual Sciences, Havener Eye Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee","family":"Ramsey","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Department of Ophthalmology and Visual Sciences, Havener Eye Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McElroy","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Department of Biomedical Informatics, College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Schreiner","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Wolfe","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6827-0552","authenticated-orcid":false,"given":"Olivia B.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Havener Eye Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Davidorf","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Department of Ophthalmology and Visual Sciences, Havener Eye Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-4968","authenticated-orcid":false,"given":"Colleen M.","family":"Cebulla","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Department of Ophthalmology and Visual Sciences, Havener Eye Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-7894","authenticated-orcid":false,"given":"Mohamed H.","family":"Abdel\u2010Rahman","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute  Columbus Ohio USA"},{"name":"Division of Human Genetics, Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"},{"name":"Department of Ophthalmology and Visual Sciences, Havener Eye Institute The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010010\u20109328\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-816222-4.00009-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.11.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2015.1010734"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8828"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa047"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/513891"},{"key":"e_1_2_12_9_1","unstructured":"Genetic\/Familial High\u2010Risk Assessment: Breast Ovarian Pancreatic and Prostate.2025.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_bopp.pdf."},{"key":"e_1_2_12_10_1","unstructured":"Genetic\/Familial High\u2010Risk Assessment: Colorectal Endometrial and Gastric.2025.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_ceg.pdf."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.1119"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.039"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251\u2010019\u201001108\u2010x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010019\u201005415\u20105"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010023\u201001448\u2010z"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2025.1779"},{"key":"e_1_2_12_17_1","volume-title":"Presentation: Patient With Uveal Melanoma\u2014In the Clinic","author":"Lucas D. 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