{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:47:33Z","timestamp":1785818853390,"version":"3.56.0"},"reference-count":83,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Melanoma is an aggressive skin cancer that, once metastatic, accounts for a disproportionate share of skin\u2010cancer mortality. Contemporary management includes surgical excision with sentinel\u2010node assessment, adjuvant or neoadjuvant systemic therapy, radiotherapy in selected settings, targeted inhibition for BRAF\/MEK\u2010mutant disease, and intralesional modalities; nevertheless, many patients require effective systemic options. Immunotherapy has transformed outcomes by restoring antitumor T\u2010cell activity. Within this paradigm, activation of CD40, a pivotal costimulatory receptor on antigen\u2010presenting cells (APCs), has emerged as a means to reprogram tumor immunity in melanoma. Available agents span several classes, including agonist monoclonal antibodies, CD40L\u2010based fusion proteins, and engineered bispecific or conditionally activatable formats. A principal mechanism is dendritic\u2010cell licensing that enhances cross\u2010priming of melanoma\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. This review summarizes the latest evidence on CD40 agonist therapy in melanoma, moving from biological rationale to translational data. We summarize mechanistic underpinnings, delineate therapeutic classes and leading agents, and critically appraise findings from preclinical models and early\u2010phase clinical studies, including signals of activity and salient safety considerations. Finally, we outline future perspectives for integrating CD40 agonists with established standards of care and for prioritizing biomarker\u2010guided development to translate preclinical promise into durable clinical benefit.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.70114","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:51:43Z","timestamp":1784958703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD40<\/scp>\n                    Agonist Therapy in Melanoma: Translating Preclinical Promise Into Clinical Practice"],"prefix":"10.1111","volume":"39","author":[{"given":"Xing","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Affiliated Hospital of Beihua University  Jilin City Jilin Province 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