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Previous studies have demonstrated that PRS is strongly associated with melanoma risk and can improve the identification of high\u2010risk individuals beyond that identified by traditional risk factors. The aim of this study was to calculate PRS for melanoma susceptibility in the Swedish population. Sixty\u2010four single nucleotide polymorphisms, previously associated with melanoma susceptibility, were used to calculate PRS for 599 melanoma patients with or without family history of melanoma and 1180 controls. PRS values were significantly higher among melanoma patients than among controls, with an area under the receiver operating characteristic curve of 0.710. Individuals in the highest PRS decile had a fourfold increased melanoma risk compared with those in the 5th\u20136th decile. PRS was strongly influenced by the pigmentation\u2010related traits skin phototype and hair color, as well as family history of melanoma and, to some extent, the number of primary melanoma tumors. The results show that PRS is strongly associated with melanoma risk in the Swedish population and may serve as a valuable tool for understanding genetic susceptibility and improving risk stratification in melanoma prevention and clinical management.<\/jats:p>","DOI":"10.1111\/pcmr.70118","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:38:02Z","timestamp":1789702682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic Risk Scores and Its Association With Cutaneous Melanoma Risk in the Swedish Population"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-4771","authenticated-orcid":false,"given":"Hildur","family":"Helgadottir","sequence":"first","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivette Raices","family":"Cruz","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Institute of Environmental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-1289","authenticated-orcid":false,"given":"Karina","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-5667","authenticated-orcid":false,"given":"Veronica","family":"H\u00f6iom","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2017.130"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju408"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.411"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000668"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21707"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.05.023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27616"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0321A"},{"key":"e_1_2_8_10_1","first-page":"4145","article-title":"Combining Common Genetic Variants and Non\u2010Genetic Risk Factors to Predict Risk of Cutaneous Melanoma","volume":"27","author":"Gu F.","year":"2018","journal-title":"Human Molecular Genetics"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2265052"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2216338"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22035"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00526.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230062"},{"key":"e_1_2_8_16_1","article-title":"TINF2 Is a Major Susceptibility Gene in Danish Patients With Multiple Primary Melanoma","volume":"4","author":"Jensen M. 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