{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:24:59Z","timestamp":1791840299526,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Aims<\/jats:title>In order to confirm the utility of the voxel\u2010based specific regional analysis system for A<\/jats:styled-content>lzheimer's disease (VSRAD<\/jats:styled-content>) in assessing the atrophy of the entorhinal cortex, we investigated whether there were correlations between VSRAD<\/jats:styled-content> and the scores of neuropsychological tests in the patients with A<\/jats:styled-content>lzheimer's disease (AD<\/jats:styled-content>) and mild cognitive impairment.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty patients, including 18 AD<\/jats:styled-content> and 12 mild cognitive impairment patients, were included in this study. VSRAD<\/jats:styled-content> was performed to assess the atrophy of the entorhinal cortex. The patients were carefully screened with the neuropsychological tests, including W<\/jats:styled-content>echsler A<\/jats:styled-content>dult I<\/jats:styled-content>ntelligence S<\/jats:styled-content>cale\u2010III<\/jats:styled-content> (WAIS\u2010III<\/jats:styled-content>), the W<\/jats:styled-content>echsler M<\/jats:styled-content>emory S<\/jats:styled-content>cale\u2010R<\/jats:styled-content>evised, the A<\/jats:styled-content>lzheimer's D<\/jats:styled-content>isease A<\/jats:styled-content>ssessment S<\/jats:styled-content>cale\u2010Cognitive Part (ADAS<\/jats:styled-content>\u2010cog) and the revised version of H<\/jats:styled-content>asegawa's D<\/jats:styled-content>ementia S<\/jats:styled-content>cale.<\/jats:p><\/jats:sec>Results<\/jats:title>All patients showed atrophy with different degrees in the entorhinal cortex except one case. Z<\/jats:styled-content>\u2010scores had significant positive correlation with ADAS<\/jats:styled-content>\u2010cog, and negative correlation with Information subset of WAIS\u2010III<\/jats:styled-content> (respectively, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0129 and P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0294). The revised version of H<\/jats:styled-content>asegawa's D<\/jats:styled-content>ementia S<\/jats:styled-content>cale and the Similarities subsets of the WAIS\u2010III<\/jats:styled-content> had a tendency of negatively correlating with Z<\/jats:styled-content>\u2010scores of VSRAD<\/jats:styled-content> (respectively, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0532 and P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0635). The D<\/jats:styled-content>elayed V<\/jats:styled-content>isual R<\/jats:styled-content>eproduction subset of the W<\/jats:styled-content>echsler M<\/jats:styled-content>emory S<\/jats:styled-content>cale\u2010R<\/jats:styled-content>evised was also found to have a weak negative correlation with Z<\/jats:styled-content>\u2010scores (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0609).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Z<\/jats:styled-content>\u2010scores of VSRAD<\/jats:styled-content> were revealed to have a close relation with many neuropsychological tests, especially ADAS<\/jats:styled-content>\u2010cog and the Information subset of WAIS\u2010III<\/jats:styled-content>. The results meant that VSRAD<\/jats:styled-content> was a useful indictor of early diagnosis of AD<\/jats:styled-content>, closely correlating with the changes of cognitive functions and the progression of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12002","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T17:00:43Z","timestamp":1355850043000},"page":"587-593","source":"Crossref","is-referenced-by-count":23,"title":["Correlations between atrophy of the entorhinal cortex and cognitive function in patients with A<\/scp>lzheimer's disease and mild cognitive impairment"],"prefix":"10.1111","volume":"66","author":[{"given":"Xudong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Neurology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuki","family":"Jibiki","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kanazawa Medical University Uchinada Japan"},{"name":"Department of Psychiatry Medical Corporation Tyokyukai Kagakokorono Hospital Kaga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Kanazawa Medical University Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2262011600"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb05866.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.037218"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00794.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.03.038"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0435-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200103260-00013"},{"key":"e_1_2_6_10_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders","author":"World Health Organization","year":"1993"},{"key":"e_1_2_6_11_1","first-page":"123","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_2_6_14_1","first-page":"231","article-title":"Imaging of brain atrophy using MRI: Comparison of early Alzheimer's disease with other dementia","volume":"19","author":"Matsuda H","year":"2005","journal-title":"Dementia Japan"},{"key":"e_1_2_6_15_1","volume-title":"Wechsler Adult Intelligence Scale\u2010III","author":"Wechsler D","year":"1997"},{"key":"e_1_2_6_16_1","volume-title":"Wechsler Memory Scale\u2010Revised Manual","author":"Wechsler D","year":"1987"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"e_1_2_6_18_1","first-page":"20","article-title":"The Revised Hasegawa's Dementia Scale (HDS\u2010R) \u2013 Evaluation of its usefulness as a screening test for dementia","volume":"4","author":"Imsi Y","year":"1994","journal-title":"J. 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