{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:21:16Z","timestamp":1791249676354,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>High serum bilirubin predicts depression in non\u2010stroke subjects, but it is unknown whether it also predicts post\u2010stroke depression (<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>). This study examined the association between the risk of <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> and bilirubin level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred and thirty\u2010five patients with acute ischemic stroke in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ong <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ong were recruited. Serum total bilirubin, alanine transaminase and alkaline phosphatase levels were measured in all patients during their hospital stay. A psychiatrist gave the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tructured <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nterview for <jats:styled-content style=\"fixed-case\">DSM\u2010IV<\/jats:styled-content> to all patients 3 months after the index stroke, with 61 patients diagnosed with <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>: 27 with major depression, 24 with minor depression and 10 with dysthymia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the full sample, the 25%, 50% and 75% percentile bilirubin levels were 7.0, 10.0 and 14.0\u2009\u03bcmol\/L, respectively. Significant differences were found between the <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> groups in terms of bilirubin level (<jats:italic>P<\/jats:italic>\u2009=\u20090.006). In post\u2010hoc comparisons, the proportion of patients with bilirubin \u226514.1\u2009\u03bcmol\/L was significantly higher in the <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> group (37.7% vs 19.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). In the final regression model, bilirubin level (\u226514.1\u2009\u03bcmol\/L) remained a significant independent predictor of <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>, with an odds ratio of 2.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High bilirubin level is associated with <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>. Further investigations are needed to clarify the underlying pathophysiological link between bilirubin level and <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12051","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T07:33:50Z","timestamp":1369035230000},"page":"259-264","source":"Crossref","is-referenced-by-count":33,"title":["Association between high serum total bilirubin and post\u2010stroke depression"],"prefix":"10.1111","volume":"67","author":[{"given":"Wai Kwong","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie Chiu Wing","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Organ Imaging Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor S.","family":"Ungvari","sequence":"additional","affiliation":[{"name":"School of Psychiatry and Clinical Neurosciences University of Western Australia  Perth Australia"},{"name":"University Notre Dame Australia\/Marian Centre  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Sing","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(97)90433-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330350"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000165928.19135.35"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00182.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.471805"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200301000-00025"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.01.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3741-04.2005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508901103"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709005637"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164110X12656393665080"},{"key":"e_1_2_6_13_1","first-page":"56","article-title":"Homocysteine as a potential biochemical marker for depression in elderly stroke survivors","volume":"11","author":"Pascoe MC","year":"2012","journal-title":"Food Nutr. 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