{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:05:37Z","timestamp":1772463937560,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Aim<\/jats:title>The present study examined the effect of irritable bowel syndrome (IBS<\/jats:styled-content>), cognitive appraisal of IBS<\/jats:styled-content>, and anxiety sensitivity on anticipatory anxiety (AA<\/jats:styled-content>) and agoraphobia (AG<\/jats:styled-content>) in patients with panic disorder (PD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We examined 244 PD<\/jats:styled-content> patients who completed a set of questionnaires that included the R<\/jats:styled-content>ome II M<\/jats:styled-content>odular Q<\/jats:styled-content>uestionnaire to assess the presence of IBS<\/jats:styled-content>, the A<\/jats:styled-content>nxiety S<\/jats:styled-content>ensitivity I<\/jats:styled-content>ndex (ASI<\/jats:styled-content>), the C<\/jats:styled-content>ognitive A<\/jats:styled-content>ppraisal R<\/jats:styled-content>ating S<\/jats:styled-content>cale (CARS<\/jats:styled-content>; assessing the cognitive appraisal of abdominal symptoms in four dimensions: commitment, appraisal of effect, appraisal of threat, and controllability), and items about the severity of AA<\/jats:styled-content> and AG<\/jats:styled-content>. The M<\/jats:styled-content>ini I<\/jats:styled-content>nternational N<\/jats:styled-content>europsychiatric Interview was used to diagnose AG<\/jats:styled-content> and PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>After excluding individuals with possible organic gastrointestinal diseases by using \u2018red flag items,\u2019 valid data were obtained from 174 participants, including 110 PD<\/jats:styled-content> patients without IBS<\/jats:styled-content> (PD<\/jats:styled-content>\/IBS<\/jats:styled-content>[\u2013]) and 64 with IBS<\/jats:styled-content> (PD<\/jats:styled-content>\/IBS<\/jats:styled-content>[+]). The PD<\/jats:styled-content>\/IBS<\/jats:styled-content>[+] group had higher AA<\/jats:styled-content> and higher comorbidity with AG<\/jats:styled-content> than the PD<\/jats:styled-content>\/IBS<\/jats:styled-content>[\u2013] group. In the PD<\/jats:styled-content>\/IBS<\/jats:styled-content>[+] group, the controllability score of CARS<\/jats:styled-content> was significantly correlated with AA<\/jats:styled-content> and ASI<\/jats:styled-content>. Multiple regression analysis showed a significant effect of ASI<\/jats:styled-content> but not of controllability on AA<\/jats:styled-content> in PD<\/jats:styled-content>\/IBS<\/jats:styled-content>[+] subjects.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study suggested that the presence of IBS<\/jats:styled-content> may be related to agoraphobia and anticipatory anxiety in PD<\/jats:styled-content> patients. Cognitive appraisal could be partly related to anticipatory anxiety in PD<\/jats:styled-content> patients with IBS<\/jats:styled-content> with anxiety sensitivity mediating this correlation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12069","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T17:04:13Z","timestamp":1374771853000},"page":"397-404","source":"Crossref","is-referenced-by-count":12,"title":["Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients"],"prefix":"10.1111","volume":"67","author":[{"given":"Nagisa","family":"Sugaya","sequence":"first","affiliation":[{"name":"Addictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan"},{"name":"Advanced Research Center for Human Sciences Waseda University Saitama 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