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A <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed search was done using the key word, \u2018<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease\u2019 in combination with the term \u2018prostaglandins\u2019. Articles from the past 10 years were preferentially selected but important ones from the past 20 years were also included according to the authors' judgment. <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease is characterized by pathological hallmarks such as extracellular deposition of the amyloid \u03b2\u2010peptide, the appearance of intracellular neurofibrillary tangles, extensive neuronal loss and synaptic changes in the cerebral cortex and hippocampus. These processes induce inflammatory pathways by activating microglia, astrocytes and infiltrating leukocytes that produce inflammatory mediators including cytokines and prostaglandins.Prostaglandins are small lipid mediators derived from arachidonic acid by multi\u2010enzymatic pathways in which cyclooxygenases and phospholipases are the rate\u2010limiting enzymes. In the central nervous system, prostaglandins exhibit either neurotoxic or neuroprotective effects by acting on specific <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\u2010protein\u2010coupled receptors that have different subfamilies and differences in their selective agonists, tissue distribution and signal transduction cascades. Further studies on the role of prostaglandins in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's disease may contribute to clarification of their neuroprotective actions, which may lead to the development of successful therapeutic strategies.<\/jats:p>","DOI":"10.1111\/pcn.12092","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T08:22:55Z","timestamp":1378110175000},"page":"50-60","source":"Crossref","is-referenced-by-count":25,"title":["Positive and negative effects of prostaglandins in <scp>A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"68","author":[{"given":"Mohammad Javad","family":"Fattahi","sequence":"first","affiliation":[{"name":"Department of Immunology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Mirshafiey","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"404","article-title":"Immunology and immunotherapy of Alzheimer's disease","volume":"6","author":"Weiner HL","year":"2006","journal-title":"Nat. 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