{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:51:39Z","timestamp":1760122299927},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Aim<\/jats:title>Significant glucose hypometabolism in the primary visual cortex (PVC<\/jats:styled-content>) is considered to support a diagnosis of dementia with L<\/jats:styled-content>ewy bodies (DLB<\/jats:styled-content>), but its relationship to the clinical features remains unknown. The purpose of this study was to assess the association between the metabolic pattern and clinical variables in DLB<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 27 DLB<\/jats:styled-content> patients who underwent [18<\/jats:sup>F<\/jats:styled-content>]fluoro\u2010d\u2010glucose (18<\/jats:sup>F<\/jats:styled-content>\u2010FDG<\/jats:styled-content>) positron emission tomography scans were examined. Demographics and clinical variables were compared between patients with and without glucose hypometabolism in the PVC<\/jats:styled-content>. The correlations between the cerebral metabolic rate of glucose in the PVC<\/jats:styled-content> and clinical variables were also investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>Only the onset age of probable rapid eye movement sleep behavior disorder (RBD<\/jats:styled-content>) was significantly different between patients with and withoutglucose hypometabolism in the PVC<\/jats:styled-content>, being younger in patients with the metabolic pattern; there were no other differences in clinical variables. The onset age of probable RBD<\/jats:styled-content> was significantly correlated with the cerebral metabolic rate of glucose in the PVC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Glucose hypometabolism in the PVC<\/jats:styled-content> provides a potential mechanism for the link between antecedent RBD<\/jats:styled-content> and the subsequent development of dementia in DLB<\/jats:styled-content> patients. Glucose hypometabolism in the PVC<\/jats:styled-content> may represent the effect of the pathophysiological process of DLB<\/jats:styled-content> on RBD<\/jats:styled-content> rather than a distinct condition in the disease progression. The physiological aspects of the link between this metabolic pattern and the onset of RBD<\/jats:styled-content> remain unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12101","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T09:58:52Z","timestamp":1383127132000},"page":"137-144","source":"Crossref","is-referenced-by-count":7,"title":["Primary visual cortical metabolism and rapid eye movement sleep behavior disorder in dementia with L<\/scp>ewy bodies"],"prefix":"10.1111","volume":"68","author":[{"given":"Yuhei","family":"Chiba","sequence":"first","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"},{"name":"Department of Psychiatry Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"},{"name":"Department of Psychiatry Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eizo","family":"Iseki","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"},{"name":"Department of Psychiatry Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"},{"name":"Department of Psychiatry Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Ota","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kasanuki","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"},{"name":"Department of Psychiatry Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heii","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Juntendo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Hirayasu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Sato","sequence":"additional","affiliation":[{"name":"PET\/CT Dementia Research Center Juntendo Tokyo Koto Geriatric Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339363"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822c9148"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1133"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2836"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05115.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.803"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.967"},{"key":"e_1_2_6_11_1","first-page":"915","article-title":"The morphologic correlate of incidental punctate white matter hyperintensities on MR images","volume":"12","author":"Fazekas F","year":"1991","journal-title":"AJNR Am. 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