{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:03:20Z","timestamp":1773867800428,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study investigated whether or not and how much milnacipran influences the indexes of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010metaiodobenzylguanidine (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIBG<\/jats:styled-content>) scintigraphy, early heart\u2010to\u2010mediastinum (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>) ratio, delayed <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> ratio, and wash\u2010out rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six elderly depressed patients participated in the study. All six patients met the diagnostic criteria for a major depressive disorder. They were taking milnacipran for their depression. They needed differential diagnosis for <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy body diseases due to their symptomatology. <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIBG<\/jats:styled-content> scintigraphy was performed twice for each subject, once under prescription of milnacipran and the other without prescription of milnacipran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both early and delayed phase <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> ratio were significantly lower when taking milnacipran (early phase <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> ratio, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohen's d 1.62; delayed phase <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> ratio, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohen's d 1.98) than when not taking the drug. Wash\u2010out rate (%) was significantly higher when taking milnacipran (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohen's d 2.31) than when off the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taking milnacipran substantially influences the indexes of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIBG<\/jats:styled-content> scintigraphy, indicating that taking the drug possibly causes a false\u2010positive result for <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy body diseases diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12111","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T08:12:12Z","timestamp":1383293532000},"page":"169-175","source":"Crossref","is-referenced-by-count":10,"title":["Milnacipran influences the indexes of <scp>I<\/scp>\u2010metaiodobenzylguanidine scintigraphy in elderly depressed patients"],"prefix":"10.1111","volume":"68","author":[{"given":"Katsutoshi","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Terachi","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghong","family":"Pu","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Division of Radiology Department of Pathophysiological Therapeutic Sciences Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Yamanashi","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Nakagome","sequence":"additional","affiliation":[{"name":"National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry Department of Brain and Neuroscience Tottori University, Faculty of Medicine  Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0135-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23659"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0239-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2180-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199207000-00006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02292766"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1520-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00905.x"},{"key":"e_1_2_6_11_1","first-page":"21","article-title":"The role of dopamine and norepinephrine in depression","volume":"14","author":"Donald S","year":"2007","journal-title":"Prim. 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