{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:22:55Z","timestamp":1774380175025,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,29]],"date-time":"2013-12-29T00:00:00Z","timestamp":1388275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Aim<\/jats:title>In J<\/jats:styled-content>apan, the government and media have become aware of the issues of early onset dementia (EOD<\/jats:styled-content>), but policies for EOD<\/jats:styled-content> have not yet been established and support systems are inadequate. To provide practical data about EOD<\/jats:styled-content>, a two\u2010step postal survey was performed.<\/jats:p><\/jats:sec>Methods<\/jats:title>A questionnaire requesting information on EOD<\/jats:styled-content> cases was sent to target institutions in five catchment areas in J<\/jats:styled-content>apan. According to the answers from the institutions, we estimated the prevalence of EOD<\/jats:styled-content> using census data and determined the illnesses causing EOD<\/jats:styled-content>. As a quality control study, the authors reviewed every diagnosis in a quarter of the reported cases using the medical and psychiatric records and neuroimaging data. This study was conducted from 2006 to 2007.<\/jats:p><\/jats:sec>Results<\/jats:title>Information from 2469 patients was collected from 12\u2009747 institutions, and 2059 subjects with EOD<\/jats:styled-content> were identified. The estimated prevalence of EOD<\/jats:styled-content> was 47.6 per 100\u2009000 (95% confidence interval, 47.1\u201348.1) for all of J<\/jats:styled-content>apan. Of the illnesses causing EOD<\/jats:styled-content>, vascular dementia (VaD<\/jats:styled-content>) was the most frequent (39.8%), followed by A<\/jats:styled-content>lzheimer's disease.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The prevalence of EOD<\/jats:styled-content> in J<\/jats:styled-content>apan appeared to be similar to that in W<\/jats:styled-content>estern countries. However, unlike previously reported international experience, VaD<\/jats:styled-content> was the most frequent cause of EOD<\/jats:styled-content> in all catchment areas in J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12127","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T01:18:50Z","timestamp":1388366330000},"page":"216-224","source":"Crossref","is-referenced-by-count":13,"title":["Multicenter population\u2010based study on the prevalence of early onset dementia in J<\/scp>apan: Vascular dementia as its prominent cause"],"prefix":"10.1111","volume":"68","author":[{"given":"Chiaki","family":"Ikejima","sequence":"first","affiliation":[{"name":"Department of Disaster Psychiatry Faculty of Medicine University of Tsukuba Ibaraki Japan"},{"name":"Department of Neuropsychiatry Faculty of Medicine University of Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropathology Faculty of Medical and Pharmaceutical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropathology Faculty of Medical and Pharmaceutical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropathology Faculty of Medical and Pharmaceutical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tanimukai","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry and Neuroscience Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kashibayashi","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Miyanaga","sequence":"additional","affiliation":[{"name":"Yukiguni\u2010Yamato Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimie","family":"Yonemura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroscience Gunma University Graduate School of Medicine Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Kakuma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Kurume University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Center for Advanced Medicine and Clinical Research Nagoya University Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Faculty of Medicine University of Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.011171"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01072.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102596"},{"key":"e_1_2_6_5_1","first-page":"424","article-title":"Estimated prevalence of presenile dementia in Tottori Prefecture","volume":"41","author":"Ohshiro H","year":"1994","journal-title":"Nippon Koushuu Eisei Zasshi"},{"key":"e_1_2_6_6_1","volume-title":"A Survey Report on the Revelation of Early\u2010Onset Dementia","author":"Ichinowatari N","year":"1997"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.542308"},{"key":"e_1_2_6_8_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_6_9_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1993"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.250"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1982.tb03109.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.773"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700025411"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1615"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1206"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg204"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3995\/jstroke.26.331"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70193-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.839"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00270.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.038"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcn.12127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.12127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:33:40Z","timestamp":1695976420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.12127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,29]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/pcn.12127"],"URL":"https:\/\/doi.org\/10.1111\/pcn.12127","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,29]]}}}