{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:21:51Z","timestamp":1787066511782,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Aim<\/jats:title>\n \n Age\u2010related sleep changes have been associated with altered hypothalamic\u2010pituitary\u2010adrenal axis reactivity and impaired feedback inhibition at the glucocorticoid (\n GR<\/jats:styled-content>\n ) and mineralocorticoid (\n MR<\/jats:styled-content>\n ) receptor level. To further investigate the specific role of this binary receptor system in the elderly, sleep electroencephalogram (\n EEG<\/jats:styled-content>\n ) effects of the\n MR<\/jats:styled-content>\n antagonist spironolactone and\n GR<\/jats:styled-content>\n antagonist mifepristone in old\u2010aged men were compared in this pilot study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Old\u2010aged healthy men (\n n<\/jats:italic>\n \u2009=\u20096, 65\u201391 years) were treated on three occasions in a single\u2010blinded design in random order with mifepristone, spironolactone and placebo, respectively, and nocturnal sleep\n EEG<\/jats:styled-content>\n was recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mifepristone led to increased wake time, decreased stage 2 and rapid eye movement (\n REM<\/jats:styled-content>\n ) sleep and prolonged\n REM<\/jats:styled-content>\n sleep latency in the first half of the night, whereas spironolactone had no considerable effects on sleep\n EEG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n GR<\/jats:styled-content>\n antagonism can potentiate age\u2010related sleep pattern alterations and further support the role of impaired\n GR<\/jats:styled-content>\n signaling in age\u2010related changes in sleep architecture.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pcn.12142","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T02:44:52Z","timestamp":1389149092000},"page":"383-387","source":"Crossref","is-referenced-by-count":5,"title":["Sleep\n EEG<\/scp>\n effects of anti\u2010gluco\u2010 and anti\u2010mineralocorticoids in old\u2010aged men: Pilot study"],"prefix":"10.1111","volume":"68","author":[{"given":"C\u00fcneyt","family":"Demiralay","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agorastos","family":"Agorastos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Steiger","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"Max Planck Institute of Psychiatry Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.04.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.861"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.1.40"},{"key":"e_1_2_6_5_1","first-page":"PCC.08m00676","article-title":"Clinical relevance of disturbances of sleep and vigilance in major depressive disorder: A review","volume":"12","author":"Thase ME","year":"2010","journal-title":"Prim. 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