{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:16:16Z","timestamp":1790021776827,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We compared the 1\u2010year rehospitalization rates of first\u2010episode bipolar manic patients who were discharged while being treated with lithium or valproate in combination with an atypical antipsychotic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the rehospitalization status of first\u2010episode bipolar manic patients who were discharged between 1 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2003 and 31 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2010 while they were taking lithium or valproate in combination with aripiprazole, olanzapine, quetiapine, or risperidone. Rehospitalization rates during a 1\u2010year period after discharge were compared between the group receiving lithium plus an atypical antipsychotic and the group receiving valproate plus an atypical antipsychotic using the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier method. A <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox regression model was used to analyze covariates hypothesized to affect time to rehospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rehospitalization rate was 17.3% during the 1\u2010year follow\u2010up period. We found significant differences in the rehospitalization rates of patients in the lithium (23.1%) and the valproate (13.3%) groups using the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier formula. According to <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazards regression analysis, higher Clinical Global Impression\u2013Bipolar Version\u2013Severity score at discharge (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and lithium treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.055) contributed to the risk of rehospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with valproate and an atypical antipsychotic can be more effective than treatment with lithium and an atypical antipsychotic in preventing rehospitalization during the 1 year after hospitalization due to a first manic episode in patients with bipolar <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> disorder. Higher Clinical Global Impression\u2013Bipolar Version\u2013Severity scores at discharge also negatively affected rehospitalization rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12145","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T07:30:37Z","timestamp":1392017437000},"page":"418-424","source":"Crossref","is-referenced-by-count":14,"title":["One\u2010year rehospitalization rates of patients with first\u2010episode bipolar mania receiving lithium or valproate and adjunctive atypical antipsychotics"],"prefix":"10.1111","volume":"68","author":[{"given":"Young Sup","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Psychiatry College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Myong","family":"Bahk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Eun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine Jeju National University  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hyun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwang\u2010Bin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hee","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kyungpook National University School of Medicine  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Heun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine Dongguk University  Gyeongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk\u2010In","family":"Jon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine Hallym University  Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Naju National Hospital  Naju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2010Doo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine Jeju National University  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Joon","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Medicine Chung\u2010Ang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70334-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.5.646"},{"key":"e_1_2_6_4_1","first-page":"128","volume-title":"Manic\u2013Depressive Illness: Bipolar Disorders and Recurrent Depression","author":"Goodwin FK","year":"2007"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Practice guideline for the treatment of patients with bipolar disorder (revision)","volume":"159","author":"American Psychiatric Association","year":"2002","journal-title":"Am. 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