{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:50:02Z","timestamp":1773215402145,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T00:00:00Z","timestamp":1397433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Aim<\/jats:title>We have previously found that sarcosine, a glycine transporter I<\/jats:styled-content> inhibitor, can improve the psychiatric symptoms of schizophrenia. In this study, we aimed to investigate whether the agent can also ameliorate neuropsychiatric symptoms of Parkinson's disease (PD<\/jats:styled-content>) patients with dementia.<\/jats:p><\/jats:sec>Methods<\/jats:title>An 8\u2010week, double\u2010blind, placebo\u2010controlled trial was conducted in patients who had PD<\/jats:styled-content> with dementia (PD\u2010D<\/jats:styled-content>). Neuropsychiatric manifestations were measured before and at week 2 (V<\/jats:styled-content>1), week 4 (V<\/jats:styled-content>2) and week 8 (V<\/jats:styled-content>3) after treatment. Linear regression with the generalized estimating equations was applied for data analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifteen patients were randomized into a sarcosine group; the other 15 into a placebo group. The generalized estimating equations model revealed significant differences in H<\/jats:styled-content>amilton D<\/jats:styled-content>epression R<\/jats:styled-content>ating S<\/jats:styled-content>cale score (P<\/jats:italic>\u2009=\u20090.049) at V<\/jats:styled-content>1 and N<\/jats:styled-content>europsychiatry I<\/jats:styled-content>nventory (P<\/jats:italic>\u2009=\u20090.039) at V<\/jats:styled-content>2 between the treatment and placebo groups. By excluding the advanced patients from analysis, there were significant differences in U<\/jats:styled-content>nified P<\/jats:styled-content>arkinson's D<\/jats:styled-content>isease R<\/jats:styled-content>ating S<\/jats:styled-content>cale V<\/jats:styled-content>2 (P<\/jats:italic>\u2009=\u20090.004) and V<\/jats:styled-content>3 (P<\/jats:italic>\u2009=\u20090.040), H<\/jats:styled-content>amilton D<\/jats:styled-content>epression R<\/jats:styled-content>ating S<\/jats:styled-content>cale V<\/jats:styled-content>1 (P<\/jats:italic>\u2009=\u20090.014) and V<\/jats:styled-content>2 (P<\/jats:italic>\u2009=\u20090.047), N<\/jats:styled-content>europsychiatry I<\/jats:styled-content>nventory V<\/jats:styled-content>1 (P<\/jats:italic>\u2009=\u20090.002) and V<\/jats:styled-content>2 (P<\/jats:italic>\u2009<\u20090.001) and B<\/jats:styled-content>ehavior P<\/jats:styled-content>athology in A<\/jats:styled-content>lzheimer's D<\/jats:styled-content>isease R<\/jats:styled-content>ating S<\/jats:styled-content>cale V<\/jats:styled-content>2 (P<\/jats:italic>\u2009=\u20090.025) in favor of sarcosine.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Sarcosine temporally improved depression and neuropsychiatric symptoms in PD\u2010D<\/jats:styled-content> patients without exacerbating the motor or cognitive features; the beneficial effects were more prominent in patients with mild\u2013moderate severity. Enhancement of N<\/jats:styled-content>\u2010methyl\u2010D<\/jats:styled-content>\u2010aspartate receptor\u2013glycine cascade may lead to a novel path for the management of PD\u2010D<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12175","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T10:10:36Z","timestamp":1393409436000},"page":"692-700","source":"Crossref","is-referenced-by-count":34,"title":["Activation of N<\/scp>\u2010methyl\u2010D<\/scp>\u2010aspartate receptor glycine site temporally ameliorates neuropsychiatric symptoms of P<\/scp>arkinson's disease with dementia"],"prefix":"10.1111","volume":"68","author":[{"given":"Chon\u2010Haw","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Neurology China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Neural and Cognitive Sciences China Medical University Taichung Taiwan"},{"name":"School of Medicine, Medical College China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Chun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine, Medical College China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bey\u2010Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Ing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Research China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Kuei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine, Medical College China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-9506","authenticated-orcid":false,"given":"Xianxiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Children's Hospital China Medical University Hospital Taichung Taiwan"},{"name":"Department of Public Health China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Chieh","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical College Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Wan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine, Medical College China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien\u2010Yuan","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Psychiatry China Medical University Hospital Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science, Medical College China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21507"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e3181a968df"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.04.038"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.02.020"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70165-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300907"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.03.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7901908"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.11.1196"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21667"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199609)11:9<819::AID-GPS389>3.0.CO;2-S"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52423.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610294001602"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213869.32676.d8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.01.024"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001386"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.856"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2012.03.006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2011.00247.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25306"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.01.044"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.06.008"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.051"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11030347"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcn.12175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.12175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:35:51Z","timestamp":1696019751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.12175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,14]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/pcn.12175"],"URL":"https:\/\/doi.org\/10.1111\/pcn.12175","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,14]]}}}