{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T11:04:32Z","timestamp":1768647872090,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Daeho Ethnic Psychiatry Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>An association between white matter hyperintensities (<jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>) and cognitive dysfunction has long been recognized. However, subjects with identically appearing <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content> on magnetic resonance imaging present with a wide variance in cognitive function ranging from normal cognition to dementia. The aim of this study was to compare cortical atrophy and integrity of white matter of patients with subcortical vascular dementia of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>inswanger type (<jats:styled-content style=\"fixed-case\">SVaD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content>) with those of the normal cognition group with <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ncWMH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with <jats:styled-content style=\"fixed-case\">SVaD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> and 11 age\u2010, sex\u2010, education\u2010 and grade of <jats:styled-content style=\"fixed-case\">WMH<\/jats:styled-content>\u2010matched <jats:styled-content style=\"fixed-case\">ncWMH<\/jats:styled-content> underwent magnetic resonance imaging, including 3\u2010D volumetric images for cortical atrophy and diffusion tensor imaging for integrity of white matter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to <jats:styled-content style=\"fixed-case\">ncWMH<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SVaD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> patients showed cortical atrophies in frontal (i.e. frontal pole, precentral gyrus and frontal medial cortex) and occipital areas (i.e. lingual gyrus) followed by atrophies in temporal (i.e. fusiform cortex and middle temporal gyrus) areas. Along with cortical atrophies, reduced integrity with low fractional anisotropy and high mean diffusivity values in genu and splenium of the corpus callosum were detected in <jats:styled-content style=\"fixed-case\">SVaD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that cognitive decline from <jats:styled-content style=\"fixed-case\">ncWMH<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">SVaD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> may be associated with cortical atrophy and reduced integrity of white matter.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12196","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T02:54:44Z","timestamp":1398740084000},"page":"821-832","source":"Crossref","is-referenced-by-count":18,"title":["Cortical atrophy, reduced integrity of white matter and cognitive impairment in subcortical vascular dementia of <scp>B<\/scp>inswanger type"],"prefix":"10.1111","volume":"68","author":[{"given":"Won\u2010Beom","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and FIRST Inje University  Gimhae Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Woong","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and FIRST Inje University  Gimhae Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical School Haeundae Paik Hospital Inje University  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University Hospital  Busan Korea"},{"name":"Medical Research Institute Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Dae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University Hospital  Busan Korea"},{"name":"Medical Research Institute Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University Hospital  Busan Korea"},{"name":"Medical Research Institute Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunsoo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University Hospital  Busan Korea"},{"name":"Medical Research Institute Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University Hospital  Busan Korea"},{"name":"Medical Research Institute Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young In","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pusan National University Yangsan Hospital  Yangsan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540080076020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.10.1654"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000183615.07936.b6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.204685"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210000384"},{"key":"e_1_2_6_7_1","first-page":"III143","article-title":"Multilevel transneuronal degeneration after brain damage. 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