{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:52:32Z","timestamp":1793310752894,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">DSM\u2010IV<\/jats:styled-content> recognizes some subtypes of major depressive disorder (<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>). It is known that the effectiveness of antidepressants differs among the <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> subtypes, and thus the differentiation of the subtypes is important. However, little is known as to structural brain changes in <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> with atypical features (<jats:styled-content style=\"fixed-case\">aMDD<\/jats:styled-content>) in comparison with <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> with melancholic features (<jats:styled-content style=\"fixed-case\">mMDD<\/jats:styled-content>), which prompted us to examine possible differences in white matter integrity assessed with diffusion tensor imaging (<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>) between these two subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were 21 patients with <jats:styled-content style=\"fixed-case\">mMDD<\/jats:styled-content>, 24 with <jats:styled-content style=\"fixed-case\">aMDD<\/jats:styled-content>, and 37 age\u2010 and sex\u2010matched healthy volunteers whose <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> data were obtained by 1.5 tesla magnetic resonance imaging. We compared fractional anisotropy and mean diffusivity value derived from <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> data on a voxel\u2010by\u2010voxel basis among the two diagnostic groups and healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant decreases of fractional anisotropy and increases of mean diffusivity in patients with <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> compared with healthy subjects in the corpus callosum, inferior fronto\u2010occipital fasciculus, and left superior longitudinal fasciculus. However, we detected no significant difference in any brain region between <jats:styled-content style=\"fixed-case\">mMDD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">aMDD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that patients with <jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content> had reduced white matter integrity in some regions; however, there was no major difference between <jats:styled-content style=\"fixed-case\">aMDD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">mMDD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12255","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T08:31:20Z","timestamp":1415694680000},"page":"360-368","source":"Crossref","is-referenced-by-count":64,"title":["White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study"],"prefix":"10.1111","volume":"69","author":[{"given":"Miho","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Center Hospital of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiology National Center Hospital of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daimei","family":"Sasayama","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Teraishi","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Obu","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kunugi","sequence":"additional","affiliation":[{"name":"Department of Mental Disorder Research National Institute of Neuroscience National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.138"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.1.31"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.1.70"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462007000500005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.100"},{"key":"e_1_2_6_8_1","first-page":"11","article-title":"Recognition and diagnosis of atypical depression","volume":"68","author":"Thase ME","year":"2007","journal-title":"J. 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