{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:45:52Z","timestamp":1785447952578,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","award":["2013R1A1A2013878"],"award-info":[{"award-number":["2013R1A1A2013878"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["CRI 15011-1"],"award-info":[{"award-number":["CRI 15011-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Patients with generalized anxiety disorder (<jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>) suffer the symptoms of psychological distress, including excessive and uncontrollable anxiety. Until now, the functional neuroanatomy for working memory (<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>) in conjunction with the major anxiety symptoms in <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> patients has not yet been clearly identified. This study investigated the neural activation patterns associated with the effect of neutral and anxiety\u2010inducing distractors during the delayed\u2010response <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> task in <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen patients with <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> and 18 age\u2010matched healthy controls participated in this study. The functional magnetic resonance images were obtained while the subjects performed a delayed\u2010response <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> task with neutral and anxiety\u2010inducing distractors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the neutral distractor, <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> patients compared to controls showed significantly lower activities in the fusiform gyrus, superior parietal gyrus, precuneus, superior occipital gyrus, lingual gyrus, cuneus, calcarine gyrus, parahippocampal gyrus and cerebellar cortex. During the anxiety\u2010inducing distractor, <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> patients showed significantly higher activity in the hippocampus, whereas they showed lower activities in the dorsolateral prefrontal cortex, fusiform gyrus, superior parietal gyrus, precuneus, superior occipital gyrus and cerebellar cortex. The blood\u2010oxygen\u2010level dependent signal changes in the dorsolateral prefrontal cortex in <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> patients during the anxiety\u2010inducing distractor were negatively correlated with <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nxiety <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ensitivity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>evised scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified the specific brain areas associated with the interaction between emotional regulation and cognitive function associated with neutral and anxiety\u2010inducing distractors during <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> maintenance in <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> patients. These findings will be helpful for understanding the neural mechanism on the <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\u2010related cognitive deficits and emotional dysfunction with typical anxiety symptoms in <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12295","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T13:34:25Z","timestamp":1426599265000},"page":"609-619","source":"Crossref","is-referenced-by-count":59,"title":["Functional neuroanatomy on the working memory under emotional distraction in patients with generalized anxiety disorder"],"prefix":"10.1111","volume":"69","author":[{"given":"Chung\u2010Man","family":"Moon","sequence":"first","affiliation":[{"name":"Research Institute for Medical Imaging Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang\u2010Woo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Research Institute for Medical Imaging Chonnam National University Medical School  Gwangju Republic of Korea"},{"name":"Department of Radiology Chonnam National University Hospital Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-005-1651-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2008.04.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31803c550d"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.06.006"},{"key":"e_1_2_6_6_1","first-page":"53","article-title":"Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety","volume":"11","author":"Ballenger JC","year":"2001","journal-title":"J. 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