{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:28:33Z","timestamp":1790674113590,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Alexithymia is a personality trait that consists of difficulty in identifying and acknowledging one's own and others' feelings. Recent studies reported that alexithymia is present in both anorexia (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) and bulimia nervosa (<jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>). Brain morphological studies on healthy subjects showed that alexithymia correlates with several brain regions involved in emotions processing. The aim of this study was to investigate the anatomical correlates of alexithymia in <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a voxel\u2010based morphometry study on 21 patients with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and 18 with <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>. Seventeen healthy subjects were used as a control group. Alexithymia, depression and anxiety were assessed with self\u2010administered questionnaires and correlated to gray matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) density in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>, alexithymia was correlated with the <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> of the parietal lobe, in particular of the right angular gyrus. The correlation was predominantly linked with Difficulty Describing Feelings. In <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>, we did not find correlations between <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> and alexithymia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content>, our results support the hypothesis that this trait may represent a relevant pathogenic or maintenance factor that contributes to relational difficulties, present in this pathology. In <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>, the lack of correlation between <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volume and alexithymia may be influenced by atrophy in several brain regions that in turn can be, as previously reported, a consequence of caloric restriction. Also, the nature of alexithymia may be different from that of <jats:styled-content style=\"fixed-case\">BN<\/jats:styled-content> and controls and this trait could be secondary to a psychopathologic process specific to <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12318","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T10:41:18Z","timestamp":1431513678000},"page":"708-716","source":"Crossref","is-referenced-by-count":29,"title":["Brain correlates of alexithymia in eating disorders: A voxel\u2010based morphometry study"],"prefix":"10.1111","volume":"69","author":[{"given":"Federico","family":"D'Agata","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"},{"name":"Besta Neurological Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Amianto","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Spalatro","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella M.","family":"Caglio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bergui","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"},{"name":"Radiology Section AOU Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Lavagnino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center (UTHealth)  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorico","family":"Righi","sequence":"additional","affiliation":[{"name":"Radiology Section AOU Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Abbate\u2010Daga","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pinessi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mortara","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Secondo","family":"Fassino","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.12.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.10219"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.02.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2007.03.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00578-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00601-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90006-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90005-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(96)00228-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(03)00099-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-004-0351-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.01.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-13-14"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2211"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20826"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2170"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Alexithymia in eating disorders: Therapeutic implications","volume":"8","author":"Pinna F","year":"2015","journal-title":"Psychol. 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