{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:35:02Z","timestamp":1790163302157,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      In the present study, our aim was to investigate the oxidative\u2013antioxidative systems in unmedicated first\u2010episode psychosis (\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      ) patients at the beginning and after short\u2010term treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study consisted of 29 patients who experienced an\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      and 25 control subjects. In order to investigate the oxidative status, we determined plasma malondialdehyde (\n                      <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                      ) levels, oxidizability of red blood cells, oxidation and oxidizability of apolipoprotein\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      \u2010containing lipoproteins (apo\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      \u2010basal\n                      <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                      and apo\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      \u2010\u0394\n                      <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                      ). In order to evaluate the antioxidative defense, we measured serum total antioxidative capacity, uric acid, albumin, total bilirubin and vitamin E levels and serum paraoxonase\/arylesterase, whole blood glutathione peroxidase (\n                      <jats:styled-content style=\"fixed-case\">GPx<\/jats:styled-content>\n                      ) and red blood cell superoxide dismutase activities before and after 6 weeks of treatment in patients with\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma\n                      <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                      and apo\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      \u2010basal\n                      <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                      levels and red blood cell superoxide dismutase activity were significantly higher and serum arylesterase and whole blood\u2010\n                      <jats:styled-content style=\"fixed-case\">GPx<\/jats:styled-content>\n                      activities were lower in the\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      group than those of the healthy control group. There were not any significant changes in the oxidative and antioxidative system parameters (except increased vitamin E levels) after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results of this study suggest that\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      is accompanied by oxidative stress. However, further studies are needed to clarify the role of oxidative stress in the physiopathologic mechanisms of\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      , so that oxidative and antioxidative system parameters can be used in the management of these patients. In accordance with psychiatric evaluation, for a better management, patients with\n                      <jats:styled-content style=\"fixed-case\">FEP<\/jats:styled-content>\n                      may require a multidisciplinary approach, including oxidative and antioxidative system parameters.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.12333","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T12:46:11Z","timestamp":1436877971000},"page":"699-707","source":"Crossref","is-referenced-by-count":57,"title":["First\u2010episode psychosis is associated with oxidative stress: Effects of short\u2010term antipsychotic treatment"],"prefix":"10.1111","volume":"69","author":[{"given":"Asli","family":"Sarandol","sequence":"first","affiliation":[{"name":"Departments of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Sarandol","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Uludag University Medical Faculty  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer Ebru","family":"Acikgoz","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Uludag University Medical Faculty  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salih Saygin","family":"Eker","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cengiz","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melehat","family":"Dirican","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Uludag University Medical Faculty  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145707008401"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_56"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90104-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00282-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00184-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.03.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.176.3.290"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.167"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.01.008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.630408"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.09.017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.07.002"},{"key":"e_1_2_6_16_1","first-page":"PCC.11r01198","article-title":"Pharmacologic treatment of first\u2010episode schizophrenia: A review of the literature","volume":"14","author":"Thomas SP","year":"2012","journal-title":"Prim. Care Companion CNS Disord."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp129"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(96)90144-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-26"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3371\/CSRP.5.4.5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.01.037"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540260600581993"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.117"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-011-0193-7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329102800514"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)90144-9"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00530-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1972.tb03486.x"},{"key":"e_1_2_6_30_1","first-page":"2020","volume-title":"Tietz Textbook of Clinical Chemistry","author":"Fairbanks V","year":"1994"},{"key":"e_1_2_6_31_1","first-page":"222","volume-title":"Practical Clinical Biochemistry, Hormones, Vitamins, Drugs and Poisons","author":"Varley H","year":"1976"},{"key":"e_1_2_6_32_1","first-page":"1126","article-title":"The human serum paraoxonase\/arylesterase polymorphism","volume":"35","author":"Eckerson HW","year":"1983","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_6_33_1","first-page":"391","article-title":"A new automated method for phenotyping arylesterase (E.C.3.1.1.2.) based upon inhibition of enzymatic hydrolysis of 4\u2010nitrophenyl acetate by phenyl acetate","volume":"30","author":"Haagen L","year":"1992","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00334-6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00030-7"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.07.024"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.03.025"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00407-3"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(95)00049-6"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-124"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.284"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.08.044"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181f0580e"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcn.12333","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.12333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:48:45Z","timestamp":1696024125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.12333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/pcn.12333"],"URL":"https:\/\/doi.org\/10.1111\/pcn.12333","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}