{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:48:02Z","timestamp":1780570082838,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Soonchunhyang University Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We examined prescription patterns in maintenance treatment for recovered bipolar patients and compared these with acute treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using retrospective methods, the bipolar patients in clinical recovery (Clinical Global Impression Bipolar Version score\u2009\u2264\u20092 for 6 months) after acute episode were selected. We reviewed differences between prescription patterns at remission and after a maintenance period of at least 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 340 bipolar disorder patients were selected. During the maintenance period, more than half of the patients (192, 56.5%) took a mood stabilizer (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>)\u2009+\u2009antipsychotic (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>) combination. Among the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>, valproate (149, 43.8%) was most prescribed, and lithium (98, 28.8%) was second, but as patients moved into maintenance treatment, lithium use decreased, and the use of lamotrigine (86, 25.3%) increased. Preferred <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> were quetiapine (125, 36.8%), aripiprazole (67, 19.7%), risperidone (48, 14.1%), and olanzapine (39, 11.5%). The use of olanzapine in maintenance was greatly decreased compared with that during acute treatment (67, 19.7%). Most patients did not take an antidepressant (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), but the proportion using one or more <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was increased during maintenance (17.9% to 30.3%), and bupropion (28, 8.2%) was the preferred <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Doses were decreased in all drugs, but lamotrigine was maintained at a dose of 133.2\u2009\u00b1\u200968.5\u2009mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most common prescription combination for bipolar maintenance treatment was <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>. The use of <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> was decreased, whereas the use of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in combination with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> was increased. The doses of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> were generally decreased during the maintenance periods, with the exception of lamotrigine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12337","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T07:24:13Z","timestamp":1438673053000},"page":"42-50","source":"Crossref","is-referenced-by-count":13,"title":["Current prescription pattern of maintenance treatments for bipolar patients in Korea: A focus on the transition from acute treatments"],"prefix":"10.1111","volume":"70","author":[{"given":"Hoo Rim","family":"Song","sequence":"first","affiliation":[{"name":"Department of Psychiatry, College of Medicine Soonchunhyang University Cheonan Hospital  Cheonan 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Hospital  Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine Kyungpook National University Hospital  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanghun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine Dongguk University Gyeongju Hospital  Gyeongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inki","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Keyo Hospital Keyo Medical Foundation  Uiwang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Goo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, Haeudae Paik Hospital and Paik Institute for Clinical Research Inje University  Busan 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