{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:30:55Z","timestamp":1792013455545,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T00:00:00Z","timestamp":1466899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medicine & Health Science and Technology Projects of Guangzhou","award":["20121A011091"],"award-info":[{"award-number":["20121A011091"]}]},{"DOI":"10.13039\/100012650","name":"Guangzhou Huiai Hospital","doi-asserted-by":"crossref","award":["2015-2016"],"award-info":[{"award-number":["2015-2016"]}],"id":[{"id":"10.13039\/100012650","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Aim<\/jats:title>\n \n The aim of this updated meta\u2010analysis was to further assess the effectiveness of cognitive behavioral therapy (\n CBT<\/jats:styled-content>\n ) in treating bipolar disorder (\n BD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We carried out a literature search on\n P<\/jats:styled-content>\n ubMed,\n E<\/jats:styled-content>\n mbase, and the\n C<\/jats:styled-content>\n ochrane\n L<\/jats:styled-content>\n ibrary up to\n O<\/jats:styled-content>\n ctober 2015. We calculated the pooled relative risk of relapse rate and standard mean difference (\n SMD<\/jats:styled-content>\n ) of mean change (data at a follow\u2010up time\u2010point \u2013 baseline) of the Beck Depression Inventory, Beck Hopelessness Scale, Hamilton Rating Scale for Depression, Young Mania Rating Scale (YMRS) and Mania Rating Scale scores with their 95% confidence interval (95%\n CI<\/jats:styled-content>\n ). Subgroup analyses based on follow\u2010up time were performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nine randomized controlled trials with 520 bipolar\n I<\/jats:styled-content>\n or\n II<\/jats:styled-content>\n disorder patients were reanalyzed. Overall analysis showed that\n CBT<\/jats:styled-content>\n did not significantly reduce the relapse rate of\n BD<\/jats:styled-content>\n or improve the level of depression. However, significant efficacy of\n CBT<\/jats:styled-content>\n in improving severity of mania was proved based on the\n YMRS<\/jats:styled-content>\n (\n SMD<\/jats:styled-content>\n \u2009=\u2009\u22120.54, 95%\n CI<\/jats:styled-content>\n , \u22121.03 to \u22120.06,\n \n P<\/jats:italic>\n <\/jats:styled-content>\n \u2009=\u20090.03) but not based on\n MRS<\/jats:styled-content>\n . Subgroup analyses showed that\n CBT<\/jats:styled-content>\n had short\u2010term efficacy in reducing relapse rate of\n BD<\/jats:styled-content>\n (at 6\u2009months\u2019 follow\u2010up: relative risk =\u20090.49, 95%\n CI<\/jats:styled-content>\n : 0.29\u20130.81,\n \n P<\/jats:italic>\n <\/jats:styled-content>\n \u2009=\u20090.006) and improving severity of mania based on\n YMRS<\/jats:styled-content>\n score (post\u2010treatment:\n SMD<\/jats:styled-content>\n \u2009=\u2009\u22120.30, 95%\n CI<\/jats:styled-content>\n , \u22120.59 to \u22120.01,\n \n P<\/jats:italic>\n <\/jats:styled-content>\n \u2009=\u20090.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Short\u2010term efficacy of\n CBT<\/jats:styled-content>\n in reducing relapse rate of\n BD<\/jats:styled-content>\n and improving the severity of mania was proved. But these effects could be weakened by time. In addition, there was no effect of\n CBT<\/jats:styled-content>\n on level of depression in\n BD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pcn.12399","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T01:37:00Z","timestamp":1463189820000},"page":"351-361","source":"Crossref","is-referenced-by-count":32,"title":["Effectiveness of cognitive behavioral therapy in treating bipolar disorder:\n A<\/scp>\n n updated meta\u2010analysis with randomized controlled trials"],"prefix":"10.1111","volume":"70","author":[{"given":"Bi\u2010Yu","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze\u2010Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Medical School The University of Texas Health Science Center Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ping","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui\u2010Yun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Dong","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Guangzhou Huiai Hospital (Guangzhou Psychiatric Hospital) The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.1006e12"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228249"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1394"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12087"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00131746-200609000-00002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.037887"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0312"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/24992"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08040488"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370805300709"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08r04559yel"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0215"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320738"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.2.145"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15433710903176088"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462011000200009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0038655"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711002522"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005557911051"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00852.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001793"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00803.x"},{"key":"e_1_2_8_26_1","first-page":"163","article-title":"Therapist 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