{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:03:29Z","timestamp":1789747409338,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T00:00:00Z","timestamp":1486252800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2017,2]]},"abstract":"\n Aim<\/jats:title>\n \n The aim of the present study was to examine whether depression and anxiety disorder manifest different autonomic dysregulations using heart\u2010rate variability (\n HRV<\/jats:styled-content>\n ) and heart rate (\n HR<\/jats:styled-content>\n ) measurements.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n HRV<\/jats:styled-content>\n and\n HR<\/jats:styled-content>\n were recorded both at rest and during task execution (random\u2010number generation) in first\u2010onset drug\u2010na\u00efve patients with major depressive disorder (\n MDD<\/jats:styled-content>\n ,\n n<\/jats:italic>\n = 14) and generalized anxiety disorder (\n GAD<\/jats:styled-content>\n ,\n n<\/jats:italic>\n = 11) as well as in healthy controls (\n n<\/jats:italic>\n = 41). The patients showed no comorbidity of depression and anxiety disorder.\n GAD<\/jats:styled-content>\n patients did not exhibit panic or phobic symptoms at the time of measurement. Following power spectrum analysis of\n HR<\/jats:styled-content>\n trend, the high\u2010 (\n HF<\/jats:styled-content>\n ) and low\u2010frequency (\n LF<\/jats:styled-content>\n ) components, the sum (\n LF<\/jats:styled-content>\n +\n HF<\/jats:styled-content>\n ), and the\n LF\/HF<\/jats:styled-content>\n ratio were compared among the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the\n MDD<\/jats:styled-content>\n patients, as previously reported,\n HF<\/jats:styled-content>\n was low and the\n LF\/HF<\/jats:styled-content>\n ratio was high during the initial\u2010rest condition, and\n HF<\/jats:styled-content>\n was less reactive to the task. In contrast,\n GAD<\/jats:styled-content>\n patients showed significantly high\n HF<\/jats:styled-content>\n , although autonomic reactivity was not impaired.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results indicate that baseline autonomic activity and its reactivity to behavioral changes are different between\n MDD<\/jats:styled-content>\n and\n GAD<\/jats:styled-content>\n in the early stage of illness. High parasympathetic tone in\n GAD<\/jats:styled-content>\n may reflect responses of the parasympathetic system to anxiety.\n MDD<\/jats:styled-content>\n is accompanied by an autonomic shift toward sympathetic activation and a reduced reactivity to task.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pcn.12494","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T12:32:13Z","timestamp":1481977933000},"page":"135-145","source":"Crossref","is-referenced-by-count":56,"title":["Major depressive disorder and generalized anxiety disorder show different autonomic dysregulations revealed by heart\u2010rate variability analysis in first\u2010onset drug\u2010na\u00efve patients without comorbidity"],"prefix":"10.1111","volume":"71","author":[{"given":"Toshikazu","family":"Shinba","sequence":"first","affiliation":[{"name":"Department of Psychiatry Shizuoka Saiseikai General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.249.4.H867"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200009000-00007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.999"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.08.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.1999.00623.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.45.2.129"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.10.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2454"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00225-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.3.299"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.08.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.08.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12123"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1996)4:4<160::AID-DA2>3.0.CO;2-J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.s.7002.02"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.12.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00080"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00202-X"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2013.10.4.326"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00136-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2012.10.012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.161.6.831"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/10615806.2010.490912"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2008.11.010"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030777"},{"key":"e_1_2_8_28_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-884X(96)96070-1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-186X(200009)21:6<480::AID-BEM8>3.0.CO;2-J"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-192909000-00037"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1037\/013734"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02534083"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200301000-00009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2008.01855.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1991.tb01391.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.11.009"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.2000.91.3f.1091"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.12.1358"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.056259"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00710.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00026"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00222"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcn.12494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.12494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:02:03Z","timestamp":1694599323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.12494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/pcn.12494"],"URL":"https:\/\/doi.org\/10.1111\/pcn.12494","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}